A kind of preparation technology of compound medicine for treating chronic nephritis
A technology for chronic nephritis and a preparation process, which is applied in directions such as drug combinations, medical preparations containing active ingredients, and pharmaceutical formulations, can solve the problems of easy rejection, loss of active ingredients, and single preparation method, and achieves a simple and feasible preparation process. , improve profits, good effect
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Embodiment 1
[0017] A preparation process for a compound drug for the treatment of chronic nephritis, comprising the steps of:
[0018] 1) Weighing: Weigh each raw material according to the weight part for later use, including 80g of Cordyceps sinensis, 1200g of Astragalus membranaceus, 600g of Salvia miltiorrhiza, 600g of safflower, and 320g of jujube seed;
[0019] 2) Preparation of component A: take Cordyceps sinensis and grind it into a fine powder of Cordyceps sinensis, which is component A;
[0020] 3) Preparation of component B: Take astragalus, crush it, pass through a 200-mesh sieve, put it in a container, add three times the weight of 85% (v / v) ethanol, stir and extract at 300rpm, control the microwave power to 500W during the extraction process, The extraction time is 90 minutes; then placed at 4°C for 12 hours, filtered, and the filter residue is used for later use; the filtrate is evaporated under reduced pressure to recover ethanol, and the filtrate is concentrated to the ext...
Embodiment 2
[0035] Animal Toxicity Test
[0036]60 healthy Kunming strain mice, half male and half female, body weight 18.9±2.6g, 60 mice were randomly divided into two groups, half male and half female in each group, 30 of them were the control group, fed with normal water; the other 30 Only mouse is given the preparation prepared by embodiment 1, dosage is 200mg / kg, every day three times, application mouse is carried out toxicity experiment and shows: compare with matched group, mouse does not see obvious difference after administration, experiment observes continuously for two weeks, little The general condition, food intake, drinking water and weight gain of the rats were all normal. On the day of administration and within two weeks after administration, no animal died, suggesting that the drug has low toxicity and is safe for clinical use.
Embodiment 3
[0038] Drug efficacy comparison test
[0039] Animals: 120 SD male rats, weighing 221±19g, healthy and clean, raised in the experimental animal center of our company.
[0040] Grouping treatment: 120 SD male rats, 30 were randomly selected as the blank control group according to no significant difference in body weight, and the remaining 90 were prepared for adriamycin nephropathy model. The model rats were randomly divided into model control group (gastric administration of normal saline, dose 100 mg / kg), Example 1 group (gastric administration of the preparation produced in Example 1, dose 100 mg / kg), control group 1 (gastric administration of control The preparation produced in Example 1, dose 100mg / kg), 30 rats in each group. Gastrointestinal administration once a day for one month in a row. The rats in each group were collected 24h urine volume at the beginning and end of the experiment to measure the 24h urine protein (sulfallic acid method).
[0041] Observation indi...
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