Multimode magnetic resonance imaging method for rat model under 3.0T field intensity

Abstract

The invention discloses a multimode magnetic resonance imaging method for a rat model under 3.0T field intensity. The method comprises the following steps of S1, anesthetizing the rat model, and fixing the rat model in a special coil for a rat by adopting a prone position after anesthetization; S2, performing structure image scanning on the rat model; S3, performing brain function magnetic resonance imaging scanning on the rat model; S4, performing diffusion tensor imaging scanning on the rat model, wherein diffusion sensitive gradients are 32 different directions; and S5, finally performing proton magnetic resonance spectrum scanning on the rat model: determining a hippocampus and thalamus maximum layer in a coronal image subjected to visual field expansion, and taking the maximum layer as a scanning center layer, and then collecting a hippocampus and thalamus line two-dimensional multi-voxel spectrum of the rat model. By implementing the method, the brain function magnetic resonance imaging scanning, the diffusion tensor imaging scanning and the proton magnetic resonance spectrum scanning of the rat model under the 3.0T field intensity can be standardized, and a required clear scanning image can be obtained.

Description

technical field [0001] The invention relates to a tomography imaging method, in particular to a multimodal magnetic resonance imaging method of a rat model under a 3.0T field strength. Background technique [0002] At present, 3.0T magnetic resonance (MRI) scanners have been widely and commonly used in clinical and scientific research in hospitals. Due to their better soft tissue resolution, they can be well used in the research and diagnosis of central nervous system diseases. However, at present, the most applied models for studying animal models are ultra-high-field animal magnetic resonance scanners, ranging from 4.7T to 17.2T small animal MRI scanners. However, these ultra-high-field MRIs cannot enter hospitals for clinical diagnosis of patients in the short term. The reasons are as follows: On the one hand, the US FDA has not allowed any MRI above 7T to enter clinical practice. At the same time, the FDA approval department believes that MRI scans above 8.0T are harmfu...

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Problems solved by technology

[0004] It can be seen that there are obviously inconveniences and defects in the standardization and process of the above-mentioned existing brain functional magnetic resonance imaging scanning, diffusion tensor imaging scanning, and proton magnetic resonance spectroscopy scanning technology of the rat model under the 3.0T field strength. , and needs to be further improved

In order to solve the above-mentioned problems, the relevant manufacturers have tried their best to find a solution, but for a long time no suitable design has been developed, and the general product has no suitable structure to solve the above-mentioned problems. This is obviously the relevant industry. Urgent problem

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