A vascular implant with superhydrophobic and oleophobic composite nanocoating

A nano-coating, super-hydrophobic technology, applied in the field of medical devices, can solve the problems of low compressive strength, difficulty, and increase patient pain, and achieve the effect of increasing compressive and flexural strength, reducing contact area, and saving hospitalization costs.

Active Publication Date: 2018-08-14
SHANGHAI FIRST PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the hemodialysis catheters used clinically have low compressive strength, and there are certain difficulties when directly inserted into blood vessels. Due to the existence of negative pressure, the opening of the arterial end of the hemodialysis catheter is often attached to the wall of the blood vessel, resulting in blood from The poor flow out of the patient's body affects the normal progress of the treatment. In severe cases, the blood in the catheter may stop flowing and form a thrombus, which may damage the filter and lead to treatment failure. This not only increases the pain of the patient, but may even pose a threat. serious consequences to the patient's life

Method used

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  • A vascular implant with superhydrophobic and oleophobic composite nanocoating
  • A vascular implant with superhydrophobic and oleophobic composite nanocoating
  • A vascular implant with superhydrophobic and oleophobic composite nanocoating

Examples

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Effect test

Embodiment 1

[0033] Example 1 Deep vein catheter with superhydrophobic and oleophobic composite nanocoating

[0034] See Figure 1-Figure 3 , with figure 1 It is a partial schematic diagram of the implant surface nano-coating of the present invention, with figure 2 It is a schematic diagram of the nano-coating on the implant surface of the present invention in blood vessels, with image 3 It is a schematic diagram of the water contact angle and the hexadecane contact angle on the coating surface. The water contact angle and the hexadecane contact angle on the coating surface are all greater than 160°, and the rolling angle is less than 3°. The coating has superhydrophobicity and oleophobicity.

[0035] The present invention includes the surface of the vascular implant 3, such as the inner and outer surfaces of the deep vein catheter; the uncoated deep vein catheter is placed in the reaction chamber of the fluorocarbon polymer plasma deposition and coating equipment, and the fluorocarbon...

Embodiment 2

[0036] Example 2 Artificial blood vessel with superhydrophobic and oleophobic composite nanocoating

[0037] The present invention includes the surface of the vascular implant 3, such as the inner and outer surfaces of the artificial blood vessel; placing the uncoated artificial blood vessel in the reaction chamber of the fluorocarbon polymer plasma deposition coating equipment, using fluorocarbon as the working gas, The polymerization reaction is carried out on the surface, and a nano-coating composed of fluorocarbon polymer is formed on the inner and outer surfaces, and the thickness of the nano-coating is 400nm. The nano-coating includes an oleophobic layer 1 and a hydrophobic layer 2, and the thickness of the oleophobic layer 2 is greater than that of the hydrophobic layer 1.

Embodiment 3

[0038]Example 3 Coronary artery stent with superhydrophobic and oleophobic composite nanocoating

[0039] The present invention includes the surface of the vascular implant 3, such as the inner and outer surfaces of the coronary artery stent; the uncoated vascular stent is placed in the reaction chamber of the fluoromolybdenum polymer plasma deposition coating equipment, and the fluorocarbon is used as the working gas to form the vascular stent on the blood vessel. Polymerization is carried out on the inner and outer surfaces of the stent, and a nano-coating composed of fluorocarbon polymer is formed on the inner and outer surfaces, and the thickness of the nano-coating is 800nm. The nano-coating includes an oleophobic layer 1 and a hydrophobic layer 2, and the thickness of the oleophobic layer 2 is greater than that of the hydrophobic layer 1.

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Abstract

The invention provides a blood vessel implant with a super hydrophobic and oleophobic compound nanometer coating. The blood vessel implant comprises all implant surfaces in contact with blood such as the inner and outer surfaces of a blood vessel catheter and the inner and outer surfaces of a blood vessel substitution (artificial blood vessel), the inner and outer surfaces of a blood vessel support are coated with nanometer coatings of super hydrophobic and oleophobic coatings. The blood vessel implant with the super hydrophobic and oleophobic compound nanometer coating has the advantages that all the implant surfaces in contact with the blood have a layer of protective film formed by fluorine-containing nano-polymers, the fluorine-containing nano-polymers have good super hydrophobicity and lipophobicity, the film isolates blood and the implant surfaces, the blood and implants are prevented from direct contact, the implants are prevented from promoting a blood clotting response in the blood, and blood coagulation is prevented; meanwhile, field planting of bacteria and fungi is prevented on the implant surfaces, and infection of bacteria and fungi is prevented; at the same time, the service life of the implants is prolonged, the pain of a patient is relived, the hospitalization time is shortened, and the hospitalization cost is saved.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a blood vessel implant with a superhydrophobic and oleophobic composite nano-coating. Background technique [0002] The currently clinically used vascular implants are mainly various vascular implant catheters, guide wires, vascular substitutes and various vascular stents, all of which are made of hydrophilic and / or lipophilic materials. Vascular implant catheters, including various arteriovenous catheters, hemodialysis catheters, ECMO implanted arteriovenous catheters, etc.; vascular substitutes include various artificial blood vessels; vascular stents include various stents implanted in blood vessels, such as cardiac coronary stents, etc. . The above-mentioned vascular implants have two disadvantages. One is that the implants cause blood coagulation in the coagulation system after insertion, causing embolism of the implants due to coagulation. Because of the different ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/06A61F2/82A61M25/09A61M25/14A61M25/00A61L29/08A61L29/14A61L31/10A61L31/14A61L27/34A61L27/50
CPCA61F2/06A61F2/82A61F2210/00A61L27/34A61L27/50A61L29/085A61L29/14A61L31/10A61L31/14A61M25/0023A61M25/0045A61M25/09A61M2205/0238C08L27/12C08L83/08
Inventor 宛新建张伟星杨莹黎金臻
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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