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Application of resveratrol oligomer dip G in preparation of medicine for treating acute myeloid leukemia

An acute myeloid, resveratrol technology, applied in the field of pharmacy, can solve problems such as ineffectiveness and undiscovered, and achieve the effect of promoting cell differentiation and inhibiting cell proliferation

Active Publication Date: 2019-04-05
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, ATRA-mediated cell differentiation therapy is not effective in other types of AML
There is no report on the effect of DipG on the treatment of AML

Method used

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  • Application of resveratrol oligomer dip G in preparation of medicine for treating acute myeloid leukemia
  • Application of resveratrol oligomer dip G in preparation of medicine for treating acute myeloid leukemia
  • Application of resveratrol oligomer dip G in preparation of medicine for treating acute myeloid leukemia

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1. Pharmacological test of Dip G

[0015] 1. Cell culture

[0016] Human AML cell lines HL-60 and U937 are from the Institute of Hematology, Chinese Academy of Medical Sciences, cultured in RPMI 1640 medium (containing 10% FBS) at 37°C, 5% CO 2 in a humidified incubator.

[0017] 2. Cell proliferation experiment

[0018] HL-60 and U937 cells were seeded in a 96-well plate, and each well was seeded with 5×10 3 Cells were treated with 0, 1.875, 3.75, 7.5, 15 μM Dip G or 50 μM Rev for 0, 24, 48, 72, and 96 hours, and stained with trypan blue, and the cells were counted with a hemocytometer.

[0019] 3. Analysis of cell morphology

[0020] Place a circular cover glass in a 24-well plate, use HL-60 and U937 cells to make cell slides, and treat them with 0, 3.75, 7.5, 15 μM Dip G or 50 μM Rev for 72 hours, respectively. Cells were stained using the Wright-Giemsa staining kit, and then photographed under a light microscope at 200 times magnification.

[0021] 4. Detectio...

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Abstract

The invention discloses application of resveratrol oligomer Diptoindonesin G in the preparation of drugs for treating acute myeloid leukemia. It is discovered herein for the first time that the resveratrol oligomer Diptoindonesin G is capable of promoting differentiation and maturation of leukemia cells and inhibiting cell proliferation in order to treat acute myeloid leukemia, thereby providing a new therapy strategy for acute myeloid leukemia.

Description

technical field [0001] The patent of the invention relates to the application of resveratrol oligomer Dip G in the preparation of medicines for treating acute myeloid leukemia, which belongs to the field of pharmacy. Background technique [0002] Acute myeloid leukemia (AML) is a malignant hematological disease characterized by abnormal proliferation of bone marrow cells and inhibition of normal hematopoietic cell differentiation. The current conventional treatment of AML is to use cytotoxic drugs to target rapidly proliferating cells to control the development of the disease, but this treatment has limited effect and has relatively large side effects. All-trans retinoic acid (ATRA) has achieved good curative effect in treating acute promyelocytic leukemia (APL), a subtype of AML, by promoting the differentiation of leukemia cells. New perspectives in differentiation therapy. However, ATRA-mediated cell differentiation therapy was not effective in other types of AML. Ther...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/05A61K31/765A61P35/02
CPCA61K31/05A61K31/765
Inventor 徐强沈燕高健范旻旻向钢谭仁祥戈惠明吴雪丰
Owner NANJING UNIV
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