MMT (montmorillonite)-Gd-DTPA (diethylenetriaminepentaacetic acid) compound, synthetic method thereof and application of MMT-Gd-DTPA compound to magnetic resonance diagnosis for digestive tract

A synthesis method and compound technology are applied in the fields of chemical preparation and drug research and development, and can solve the problems of high price, low synthesis yield, poor biocompatibility of MR oral contrast agents, etc., and achieve simple method and high synthesis yield. , the effect of large clinical application potential

Inactive Publication Date: 2017-06-13
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to avoid the disadvantages of the above-mentioned prior art, the present invention provides a MMT-Gd-DTPA complex and its synthesis method and its application in the magnetic resonance diagnosis of the digestive tract. The technical problem to be solved is that the existing MR Oral contrast agents have disadvantages such as poor biocompatibility, low synthesis yield, and high price

Method used

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  • MMT (montmorillonite)-Gd-DTPA (diethylenetriaminepentaacetic acid) compound, synthetic method thereof and application of MMT-Gd-DTPA compound to magnetic resonance diagnosis for digestive tract
  • MMT (montmorillonite)-Gd-DTPA (diethylenetriaminepentaacetic acid) compound, synthetic method thereof and application of MMT-Gd-DTPA compound to magnetic resonance diagnosis for digestive tract
  • MMT (montmorillonite)-Gd-DTPA (diethylenetriaminepentaacetic acid) compound, synthetic method thereof and application of MMT-Gd-DTPA compound to magnetic resonance diagnosis for digestive tract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The present embodiment carries out the preparation of MMT-Gd-DTPA complex according to the following steps:

[0031] a. Weigh 1 g of MMT powder into a beaker, add 20 mL of deionized water, and disperse evenly to obtain solution A;

[0032] b. Add 0.5 g of GdCl to solution A 3 Disperse uniformly to obtain solution B;

[0033] C, put into baking oven after the solution B is transferred into the high-temperature reaction kettle, place 12 hours at 150 ℃, obtain reaction solution C;

[0034] d, the reaction solution C is centrifuged, and the product obtained is transferred to a freeze dryer and taken out after 24 hours of freeze drying to obtain a MMT-Gd complex;

[0035] e. Weigh 0.5 g of MMT-Gd complex into a beaker, add 20 mL of deionized water, and disperse evenly to obtain solution D;

[0036] f. Add 0.5 g of DTPA to solution D, and after stirring and ultrasonically dispersing uniformly, solution E is obtained;

[0037] g. At 60°C, the solution E prepared in step f ...

Embodiment 2

[0044] The present embodiment carries out the preparation of MMT-Gd-DTPA complex according to the following steps:

[0045] a. Weigh 3g of MMT powder into a beaker, add 40mL of deionized water, and disperse evenly to obtain solution A;

[0046] b. Add 3 g of GdCl to solution A 3 Disperse uniformly to obtain solution B;

[0047] C, put into baking oven after the solution B is transferred into the high temperature reaction kettle, and place at 180 DEG C for 24 hours to obtain reaction solution C;

[0048] d, the reaction solution C is centrifuged, and the product obtained is transferred to a freeze dryer and taken out after 24 hours of freeze drying to obtain a MMT-Gd complex;

[0049] e. Weigh 2.5 g of MMT-Gd complex into a beaker, add 40 mL of deionized water, and disperse evenly to obtain solution D;

[0050] f. Add 2.5 g of DTPA into solution D, and after stirring and ultrasonically dispersing uniformly, solution E is obtained;

[0051] g. At 75°C, the solution E prepare...

Embodiment 3

[0055] The present embodiment carries out the preparation of MMT-Gd-DTPA complex according to the following steps:

[0056] a. Weigh 1.5g of MMT powder into a beaker, add 40mL of deionized water, and disperse evenly to obtain solution A;

[0057] b. Add 1.5 g of GdCl to solution A 3 Disperse uniformly to obtain solution B;

[0058] C, put into baking oven after the solution B is transferred into the high-temperature reaction kettle, place 16 hours at 180 ℃, obtain reaction solution C;

[0059] d, the reaction solution C is centrifuged, and the product obtained is transferred to a freeze dryer and taken out after 24 hours of freeze drying to obtain a MMT-Gd complex;

[0060] e. Weigh 1 g of MMT-Gd complex into a beaker, add 40 mL of deionized water, and disperse evenly to obtain solution D;

[0061] f. Add 1 g of DTPA to solution D, and after stirring and ultrasonically dispersing uniformly, solution E is obtained;

[0062] g. At 70°C, the solution E prepared in step f was ...

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Abstract

The invention discloses an MMT (montmorillonite)-Gd-DTPA (diethylenetriaminepentaacetic acid) compound, a synthetic method thereof and an application of the MMT-Gd-DTPA compound to magnetic resonance diagnosis for a digestive tract. The synthetic method is characterized in that MMT powder and GdCl3 are mixed in water and react, MMT-Gd compound powder is obtained and reacts with DTPA in water, and the MMT-Gd-DTPA compound is obtained. The MMT-Gd-DTPA compound is obtained through hydro-thermal synthesis, the method is simple and easy to implement, the obtained compound not only has good longitudinal relaxation rate r1 and good biocompatibility, but also has good effect of adhesion to the digestive tract wall, is a better T1 magnetic resonance molecular imaging oral contrast agent and has higher clinical application potential.

Description

technical field [0001] The invention belongs to the technical field of chemical preparation and drug research and development, in particular to an MMT-Gd-DTPA compound, a synthesis method thereof, and an application as a T1 contrast agent in magnetic resonance diagnosis of digestive tract. Background technique [0002] At present, T1-weighted magnetic resonance imaging is widely used in clinical practice, and contrast agents for magnetic resonance imaging develop rapidly, but the development of MR oral contrast agents is slow, which limits the use of magnetic resonance imaging technology in the diagnosis of gastrointestinal diseases. [0003] American Journal of Physical Chemistry (J.Phys.Chem, 1996, Vol. 100, pp. 16429–16434), reported the bentonite-gadolinium ion complex obtained by intercalating bentonite with gadolinium ions. The suspension of this complex has good T1 contrast effect and can be used as MR oral contrast agent for the diagnosis of digestive tract diseases....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/10
CPCA61K49/105
Inventor 陆杨闫旭潘晓锋董良徐运军苏杨凌代舜徐维平李飞宋永红钱海生
Owner HEFEI UNIV OF TECH
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