Application of heat shock transcription factor 1 in regulating the expression of 15kda selenoprotein

A technology of transcription factor and heat shock, applied in the application of heat shock transcription factor 1 in regulating the expression of 15kDa selenoprotein, the new application field of heat shock transcription factor 1
CN106831975BActive Publication Date: 2020-12-25SHENZHEN UNIV
1 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHENZHEN UNIV
Publication Date
2020-12-25

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses an application of a heat shock transcription factor 1 in regulating expression of a 15kDa selenoprotein. The application provided by the invention is specifically any one of the applications of the heat shock transcription factor 1: (a1) promoting expression of a Sep15 protein in a target cell; (a2) promoting transcription of a Sep15 gene; and (a3) enhancing the activity of a Sep15 promoter in the target cell. According to the application disclosed by the invention, a transcription factor HSF1 can be combined with the Sep15 promoter to adjust transcription of the Sep15 gene and accelerate expression of the Sep15 protein. Under a heat shock and fever of a physiological status, the transcription factor HSF1 can start transcription of Sep15 and improve expression of Sep 15 so as to participate the physiological process and help the protein being corrected folded or help the protein being unfolded and delivered to other proteins to help the proteins to be folded correctly. Under endoplasmic reticulum stress, the HSF1 also can promote expression of Sep 15 to participate protein quality control of endoplasmic reticulum so as to further promote cell survival. The application disclosed by the invention is of important significance in preventing and / or treating endoplasmic reticulum stress related diseases.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of biotechnology, and relates to a new application of heat shock transcription factor 1, in particular to an application of heat shock transcription factor 1 in regulating the expression of 15kDa selenoprotein. Background technique

[0002] Human heat shock transcription factor 1 (HSF1) is expressed in multiple organs and tissues, and is involved in regulating the heat shock response and inducing the expression of heat shock proteins. It has a variety of biological functions, not only anti-apoptosis, protection of ischemic cardiomyocytes, inhibition of myocardial fibrosis, participation in growth and development, but also anti-inflammatory response, in myocardial cell inflammatory response, lung injury and infection, internal It plays a pivotal role in toxemia, systemic inflammatory response syndrome and other inflammation-related diseases.

[0003] Sep15 is a selenoprotein with a molecular size of 15 kDa and a thior...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More