Application of 5-hydrogen-1,4-benzodiazepine compound in treatment of liver cancer

A benzodiazepine, a technology for the treatment of liver cancer, applied in medical preparations containing active ingredients, organic chemistry, drug combinations, etc., can solve problems such as less research, achieve strong inhibitory activity, and good development and application prospects Effect
CN106902123AActive Publication Date: 2017-06-30SHANGHAI JIAO TONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI JIAO TONG UNIV
Publication Date
2017-06-30

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Abstract

The invention discloses application of a 5-hydrogen-1,4-benzodiazepine compound in treatment of the liver cancer. The 5-hydrogen-1,4-benzodiazepine compound has a good inhibition effect on human hepatocarcinoma cell lines HepG2 and Huh7; in seven tested 5-hydrogen-1,4-benzodiazepine compounds, when the concentration of the compound VII is 30 [mu]M, the rate of inhibiting the human hepatocarcinoma cell line HepG2 can be up to 70 percent, and the rate of inhibiting the human hepatocarcinoma cell line Huh7 can be up to 64 percent. The invention discloses the application of the type of compounds in preparation of a liver cancer treatment medicine; furthermore, the compounds are high in inhibition activity for hepatoma cells, so that the 5-hydrogen-1,4-benzodiazepine compound has a good development and application prospect in preparation of anti-liver cancer medicines.
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Description

technical field

[0001] The invention relates to the medical use of 5-hydrogen-1,4-benzodiazepine compounds, in particular to the application of 5-hydrogen-1,4-benzodiazepine compounds in treating liver cancer. Background technique

[0002] Benzodiazepine structural units exist in a series of natural products and drug molecules with physiological activities. For example, 1,5-benzodiazepine compounds are often used as anxiolytics, antidepressants, anticonvulsants, Drugs for sedation and analgesia; and 1,4-benzodiazepines also show good biological activity, such as drugs commonly used as anti-anxiety and antidepressants.

[0003] As an important class of 1,4-benzodiazepines, less research has been done on 5-hydrogen-1,4-benzodiazepines; among them, 5-hydrogen-1,4- The biological activity of benzodiazepines has not been reported yet. Therefore, it is of great significance to study the application of such compounds. Contents of the invention

[0004] The present invention pr...

Claims

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