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A kind of traditional Chinese medicine fine granule and preparation method thereof

A fine-grained, traditional Chinese medicine technology, which is applied in pharmaceutical formulations, drug combinations, and medical preparations containing active ingredients, etc., can solve the problems of poor solubility, inconvenience in taking traditional Chinese medicine preparations for soothing the liver and relieving depression, and difficult to meet the needs of patients for medication, etc. Easy to take, excellent melting properties, and the effect of improving medication compliance

Active Publication Date: 2021-02-19
SICHUAN JISHENGTANG PHARMLS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides a traditional Chinese medicine fine granule with outstanding taste-masking effect, good solubility, good granule quality and high product qualification rate, so as to solve the inconvenience of taking the traditional Chinese medicine preparation for soothing the liver and relieving stagnation, bitter taste, poor solubility and difficult to meet the medication needs of patients The problem

Method used

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  • A kind of traditional Chinese medicine fine granule and preparation method thereof
  • A kind of traditional Chinese medicine fine granule and preparation method thereof
  • A kind of traditional Chinese medicine fine granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074]

[0075] 1. Take Hypericum perforatum extract powder and dissolve it in an appropriate amount of ethanol to obtain extract liquid, pass through an 80-mesh sieve, and set aside.

[0076] 2. Put mannitol into the WBF-3G fluidized bed, and set the air intake to 40-50m 3 / h, the air inlet temperature is 35-45°C, the atomization pressure is 0.8-1.2bar, the material temperature is 35-45°C, and the extract is sprayed at a speed of 5-20g / ml.

[0077] 3. After the liquid spraying is finished, the prepared particles are sieved, and the fine particles that meet the required particle size are screened out.

Embodiment 2

[0079]

[0080] 1. Dissolve Acanthopanax extract powder in an appropriate amount of purified water to obtain an extract liquid, pass through a 80-mesh sieve, and set aside.

[0081] 2. Put mannitol into the WBF-3G fluidized bed, and set the air intake to 40-50m 3 / h, the air inlet temperature is 35-45°C, the atomization pressure is 0.8-1.2bar, the material temperature is 35-45°C, and the extract is sprayed at a speed of 5-20g / ml.

[0082] 3. After the liquid spraying is finished, the prepared particles are sieved, and the fine particles that meet the required particle size are screened out.

Embodiment 3

[0084]

[0085] 1. Get hypericum perforatum extract powder and dissolve in appropriate amount of 75% ethanol, get Acanthopanax acanthopanax extract powder and dissolve in appropriate amount of purified water, mix both uniformly to obtain mixed extract solution. Pass through a 80-mesh sieve and set aside.

[0086] 2. Put lactose 70 mesh into the WBF-3G fluidized bed, set the air intake to 40-50m 3 / h, the air inlet temperature is 35-45°C, the atomization pressure is 0.8-1.2bar, the material temperature is 35-45°C, and the mixed extract is sprayed at a speed of 5-20g / ml.

[0087] 3. After the liquid spraying is finished, the prepared particles are sieved, and the fine particles that meet the required particle size are screened out.

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Abstract

The invention discloses a traditional Chinese medicine fine granule and a preparing method thereof. The traditional Chinese medicine fine granule comprises a bitter taste masking mother nucleus and an active ingredient layer which covers the bitter taste masking mother nucleus, wherein the active ingredient layer comprises hypericum perforatum extract powder or extract powder of radix et caulis acanthopanacis senticosi, or the mixture of the hypericum perforatum extract powder and the extract powder of radix et caulis acanthopanacis senticosi. The fine granule is prepared through a fluidized bed pelletizing technology. The fine granule conducts bitter taste masking through the adoption of a non-isolated technology, the bitter taste masking effect is protruding, the fine granule has excellent dissolving characteristics, is high in rate of finished product, convenient to take, easy to swallow, good in mouthfeel, is more suitable for being used by senile patients and child patients, and thus the medicine taking compliance of the patients is improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a traditional Chinese medicine fine granule and a preparation method thereof. Background technique [0002] Hypericum perforatum, also known as Hypericum perforatum, is called St john's wort (commonly known as St. John's wort) in western countries. It is the dry aerial part of Hypericum perforatum L., a plant of Garcinaceae. It is cold in nature, pungent in taste, and returns to the Liver Channel. It has the effects of soothing the liver and relieving depression, clearing heat and promoting dampness, reducing swelling and dredging the milk. It is mainly used to treat diseases such as stagnation of liver qi, poor emotions, heart depression, joint swelling and pain, mastitis, and less milk; The dry roots and rhizomes or stems of Acanthopanax senticosus (Rupr. et Maxim.) Harms are warm in nature, pungent in taste, slightly bitter, and return...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/185A61K36/254A61P1/16A61P25/24
CPCA61K9/167A61K36/185A61K36/254A61K2300/00
Inventor 柯潇郑强吕静
Owner SICHUAN JISHENGTANG PHARMLS
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