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Synthesis method of 4-aminobenzamide

A technology of aminobenzamide and p-nitrobenzoic acid, which is applied in the field of synthesis of p-aminobenzamide, can solve the problems of difficult recovery of thionyl chloride, difficulty of "three wastes" treatment, large amount of waste water discharge, etc., and achieve a synthetic route The effects of reasonable setting, reduced labor load, and faster response speed

Inactive Publication Date: 2017-07-14
连云港恒贸化工有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, in the acyl chloride reaction, the thionyl chloride used is a highly toxic, highly corrosive, and highly irritating fuming liquid, and the amount used is 5 times that of p-aminobenzoic acid. Not only the production conditions are harsh, but the amount used Large, long reaction time, difficult recovery of thionyl chloride, high equipment cost, and large environmental pollution
[0008] Moreover, in the reduction reaction, a large amount of high-quality iron powder needs to be consumed for reduction with iron powder. The collection and transportation of iron powder limit large-scale production to a certain extent. bring great difficulty

Method used

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  • Synthesis method of 4-aminobenzamide
  • Synthesis method of 4-aminobenzamide
  • Synthesis method of 4-aminobenzamide

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Embodiment Construction

[0029] The present invention will be described in detail below in conjunction with specific embodiments. The following examples will help those skilled in the art to further understand the present invention, but do not limit the present invention in any form. It should be noted that those skilled in the art can make several modifications and improvements without departing from the concept of the present invention. These all belong to the protection scope of the present invention.

[0030] Acyl chloride reaction, see the reaction equation figure 1 :

[0031] Add 100g of p-nitrobenzoic acid, 213g of triphosgene and 200g of toluene into a 500ml flask, stir and cool down to below 0°C, add 10g of a mixed solution of pyridine and triethylamine (mass ratio 1:9) dropwise, after the dropwise addition is complete, raise the temperature to room temperature, reacted at room temperature for 20 hours, and collected the generated hydrogen chloride gas.

[0032] After the reaction was com...

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Abstract

The invention provides a method for synthesizing p-aminobenzamide, comprising the steps of: 1) taking a container, adding p-nitrobenzoic acid, triphosgene and a solvent, after the reaction is completed, collecting the solvent to obtain p-nitrobenzoyl chloride; ) take another reaction vessel, add ammonia and phase transfer catalyst, drop p-nitrobenzoyl chloride toluene solution to obtain p-nitrobenzamide; 3) take the reaction kettle, add p-nitrobenzamide, and add water, Catalyst, obtains described p-aminobenzamide. In the method, the amount of raw materials used is small and the reaction speed is fast. After the hydrogen chloride gas produced by the reaction is absorbed into hydrochloric acid by water, it can be used for other purposes, which effectively reduces the production cost. In the reduction reaction, the iron powder method is replaced by the hydrogenation method, so that the production The cost is reduced, no solid waste is generated, the labor load is greatly reduced, the process is environmentally friendly, and the economic benefit is good.

Description

technical field [0001] The invention belongs to the technical field of chemical product synthesis, and in particular relates to a method for synthesizing p-aminobenzamide. Background technique [0002] 4-Aminobenzamide, CAS number: 2835-68-9, chemical formula C 7 h 8 N 2 O, the molecular weight is 136.15. It is used in the manufacture of organic pigment intermediates, mainly used in the printing of cotton, rayon, and hemp fibers, dyeing and the manufacture of organic pigments for the coloring of inks and pigment printing pastes. [0003] 4-aminobenzamide is an important intermediate of medicine and pigment, and it is most widely used in the production of 170# red pigment. Its preparation generally uses p-nitrobenzoic acid as raw material, and undergoes acid chloride reaction, ammonolysis reaction and reduction reaction production. [0004] At present, the route used by most domestic enterprises to produce p-aminobenzamide is: react with p-nitrobenzoic acid and thionyl c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C231/12C07C237/30
CPCC07C231/12C07C201/12C07C231/02
Inventor 张林飞韩伟国靳牛强
Owner 连云港恒贸化工有限公司
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