A kind of venlafaxine hydrochloride sustained-release capsule composition
A technology of venlafaxine hydrochloride and sustained-release capsules, applied in the field of medicine, can solve problems such as adhesion and excessive softening of macromolecular polymers, and achieve the effect of reducing side effects and avoiding adhesion
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Embodiment 1
[0084] According to above-mentioned screening result, decide to adopt the prescription (specification: 75mg) as shown below to carry out the preparation of sustained-release capsule composition:
[0085]
[0086] The preparation method is as follows:
[0087] (1) Take by weighing 6660g of ethanol, place in a clean container, add 1273g of venlafaxine hydrochloride, stir to make the dissolution even, then slowly add 225g of hypromellose, vigorously stir to make the dispersion uniform, cross a 100 mesh sieve, and obtain Drug-loaded layer liquid;
[0088] (2) Put 1650g of microcrystalline cellulose pellet cores in a fluidized bed, set the air inlet temperature to 39°C, set the frequency, and after drying for 30 minutes, set a certain atomization pressure and needle pressure, and adjust The height of the guide tube is to make the core of the microcrystalline cellulose pellets fluidized evenly. After controlling the temperature of the material at 33-37°C, the drug-loaded layer l...
Embodiment 2
[0093] According to above-mentioned screening result, decide to adopt the prescription (specification: 150mg) as shown below to carry out the preparation of sustained-release capsule composition:
[0094]
[0095]
[0096] The preparation method is as follows:
[0097] (1) Take by weighing 6660g of ethanol, place in a clean container, add 1273g of venlafaxine hydrochloride, stir to make the dissolution even, then slowly add 225g of hypromellose, vigorously stir to make the dispersion uniform, cross a 100 mesh sieve, and obtain Drug-loaded layer liquid;
[0098] (2) Put 1650g of microcrystalline cellulose pellet cores in a fluidized bed, set the air inlet temperature to 39°C, set the frequency, and after drying for 30 minutes, set a certain atomization pressure and needle pressure, and adjust The height of the guide tube is to make the core of the microcrystalline cellulose pellets fluidized evenly. After controlling the temperature of the material to 33-37°C, start to spr...
Embodiment 3
[0103] According to above-mentioned screening result, decide to adopt the prescription (specification: 75mg) as shown below to carry out the preparation of sustained-release capsule composition:
[0104]
[0105] The preparation method is as follows:
[0106] (1) Take by weighing 9300g of ethanol, place in a clean container, add 1867g of venlafaxine hydrochloride, stir to make the dissolution even, then slowly add 320g hypromellose, vigorously stir to make the dispersion uniform, cross a 100 mesh sieve, and obtain Drug-loaded layer liquid;
[0107] (2) Put 2337g of microcrystalline cellulose pellet cores in a fluidized bed, set the air inlet temperature to 39°C, set the frequency, and after drying for 30 minutes, set a certain atomization pressure and needle pressure, and adjust The height of the guide tube is to make the core of the microcrystalline cellulose pellets fluidized evenly. After controlling the temperature of the material to 33-37°C, start to spray the core of...
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