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Medicinal composition for treating esophagus cancer and application thereof

A composition and technology for esophageal cancer, applied in the field of pharmaceutical compositions for the treatment of esophageal cancer, to achieve the effect of definite curative effect, obvious tumor growth, and simple components

Active Publication Date: 2017-07-18
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Currently, the combination of FTY720 and cisplatin has not been reported

Method used

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  • Medicinal composition for treating esophagus cancer and application thereof
  • Medicinal composition for treating esophagus cancer and application thereof
  • Medicinal composition for treating esophagus cancer and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1, the raw material formula of pharmaceutical composition of the present invention

[0032] Composition 1: FTY720 and cisplatin, the mass concentration ratio of FTY720 and cisplatin is 0.5:1.

[0033] Composition 2: FTY720 and cisplatin, the mass concentration ratio of FTY720 and cisplatin is 1.6:1.

[0034] Composition 3: FTY720 and cisplatin, the mass concentration ratio of FTY720 and cisplatin is 5:1.

Embodiment 2

[0035] Embodiment 2, antitumor effect and experiment

[0036] Study 1: Effects of cisplatin and FTY720 alone on the growth of esophageal cancer cells ( figure 1 )

[0037] To detect the drug sensitivity of two esophageal cancer cells Eca-109 and EC9706 to cisplatin and FTY720 alone.

[0038] 1.1 Experimental method

[0039] Esophageal cancer cells Eca-109 and EC9706 were inoculated into 96-well plates at the number of 4000-6000 cells per well. After the cells adhered to the wall (24 hours), the drugs cisplatin and FTY720 were diluted to a certain gradient concentration. Set up 5 replicate wells, divide into experimental group and zero adjustment group to add medicine. After 48 hours, use the MTT method to detect cell viability. Add 10 μl of MTT solution to each well and continue to incubate for 4 hours. Carefully suck out the liquid in the wells to avoid contact with crystals in the wells. Add 100 μl of DMSO to each well and shake on a constant speed shaker in the dark....

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Abstract

The invention belongs to the field of biological medicines, and particularly relates to a medicinal composition containing effective amount of FTY720 and cis-platinum for treating esophagus cancer and application thereof in preparation of medicines or health products for inhibiting proliferation and invasion of esophagus cancer cells and promoting esophagus cancer cell apoptosis. Tests prove that after FTY720 and cis-platinum are combined, the medicinal effect is synergized, the cis-platinum is promoted to induce apoptosis of esophagus cancer cells, the effect of cis-platinum for inhibiting invasion of esophagus cancer cells can be reinforced, and the toxin of cis-platinum for a human body can be reduced. The medicinal composition accords with modern medical researching theory, and provides more administration choice for clinical medical treatment of esophagus cancer.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a pharmaceutical composition for treating esophageal cancer and its application. Background technique [0002] Esophageal cancer (esophageal carcinoma, EC) is one of the most common lethal tumors in humans. my country is one of the countries with high morbidity and mortality of esophageal cancer in the world, and about 150,000 people die from esophageal cancer every year. In my country, the histological type of EC cases is mainly squamous cell carcinoma of the esophagus. Most esophageal cancers have entered the middle and late stages when they are discovered, and their prognosis is poor. Infiltration and metastasis is the main cause of death. Cancer cell invasion is the prelude to tumor metastasis, and metastasis is the continuation and result of invasion. Therefore, inhibiting cancer cell invasion can inhibit tumor metastasis to a certain extent, and finding a drug that ...

Claims

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Application Information

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IPC IPC(8): A61K33/24A61P35/00A61K31/137
CPCA61K31/137A61K33/24A61K2300/00
Inventor 王绍祥王晓钟雪云张勇王一飞王绍其
Owner JINAN UNIVERSITY
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