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Medicine for maintenance hemodialysis patients complicated with chronic heart failure and preparation method thereof

A technology for chronic heart failure and a production method, applied in the field of medicine, can solve the problems of inconvenient taking, slow effect, and unsatisfactory effect.

Active Publication Date: 2020-10-27
贵州中医药大学第二附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commercially available Qili Qiangxin Capsules have the disadvantages of unsatisfactory curative effect, inconvenient taking and slow effect

Method used

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  • Medicine for maintenance hemodialysis patients complicated with chronic heart failure and preparation method thereof
  • Medicine for maintenance hemodialysis patients complicated with chronic heart failure and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Recipe: Guizhi 9kg, Zhifuzi 6kg, Zhigancao 10kg, Astragalus 10kg, Codonopsis 10kg, Schisandra 10kg, Rehmannia glutinosa 10kg, Radix Paeoniae Alba 10kg, Poria cocos 10kg, Alisma 10kg, Gualou shell 10kg and Allium scallion 10kg.

[0043] Process: Take the above-mentioned medicine, add 9 times the amount of water to soak for 13 minutes, first decoct on high heat for 13 minutes until boiling, then continue to decoct on low heat for 20 minutes, filter, add 5 times the amount of water to the filter residue and decoct twice, each time After 30 minutes, filter and combine the filtrates to obtain the decoction.

[0044] Usage and dosage: 30ml each time, 2-3 times a day.

Embodiment 2

[0046] Recipe: Guizhi 12kg, Zhifuzi 8kg, Zhigancao 12kg, Astragalus 12kg, Codonopsis 12kg, Schisandra 12kg, Rehmannia glutinosa 12kg, Radix Paeoniae Alba 12kg, Poria 12kg, Alisma 12kg, Gualou shell 12kg and Allium scallion 12kg.

[0047] Process: Take the above medicine, add 10 times the amount of water to soak for 15 minutes, first decoct on high heat for 15 minutes, then continue to decoct on low heat for 25 minutes, decoct 3 times, filter, combine the filtrate, and the filtrate is concentrated to 50-60 ° C. For the extract with a density of 1.20-1.25, take 30% starch and 0.7% magnesium stearate to mix with the extract, granulate with 60% ethanol, dry, crush, and fill capsules to obtain capsules agent.

[0048] Specification: 0.5g / grain.

[0049] Usage and dosage: 2-3 capsules each time, 2-3 times a day.

Embodiment 3

[0051] Recipe: Guizhi 6kg, Zhifuzi 4kg, Zhigancao 8kg, Astragalus 8kg, Codonopsis 8kg, Schisandra 8kg, Rehmannia glutinosa 8kg, Radix Paeoniae Alba 8kg, Poria cocos 8kg, Alisma 8kg, Trichosanthes shell 8kg and Scallion 8kg.

[0052] Process: Take the above medicine, add 8 times the amount of water to soak for 10 minutes, first decoct on high heat for 10 minutes, then continue to decoct on low heat for 15 minutes, decoct 3 times, filter, combine the filtrate, and the filtrate is concentrated to 50-60 ℃. The extract with a density of 1.20-1.25 is mixed evenly with 20% starch of the extract, pressed into tablets, and coated with a film.

[0053] Specification: 0.5g / piece.

[0054] Usage and dosage: 2-3 tablets each time, 2-3 times a day.

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Abstract

The invention discloses a drug for maintenance hemodialysis patients with chronic heart failure and a preparation method thereof. The drug is mainly prepared from cassia twig, processed radix aconiti lateralis, honey-fried licorice root, radix astragali, Codonopsis pilosula, Schisandra chinensis, prepared rhizome of rehmannia, radix paeoniae alba, Poria cocos, Alisma plantago-aquatica, trichosanthes kirilowii shell and Allium macrostemon. The prepared drug has the efficacy of warming yang and benefiting qi, nourishing yin and consolidating depletion, relieving chest stuffiness and eliminating phlegm. Clinical study shows that the drug can significantly improve the cardiac functions of patients, even has certain effect of promoting ventricular remodeling, thus finding a new method for treatment of maintenance hemodialysis patients with chronic heart failure.

Description

technical field [0001] The invention relates to a medicine for maintenance hemodialysis patients complicated with chronic heart failure and a preparation method thereof, belonging to the field of medicine technology. [0002] technical background [0003] Chronic heart failure is a common complication in maintenance hemodialysis patients, and its etiology is related to comprehensive factors such as long-term volume overload, hypertension, anemia, electrolyte imbalance, acidosis, hyperparathyroidism, etc., resulting in decreased oxygen tolerance of the body , leading to changes in the structure of the heart, reduced myocardial contractility, arrhythmia, and eventually chronic heart failure. Especially in patients with long dialysis time (>5 years), the incidence rate can reach 100%, which seriously affects the quality of life and long-term survival of patients. Because most of these patients are anuric, diuretics are ineffective. At the same time, β receptor blockers are us...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8962A61P9/04
CPCA61K36/076A61K36/344A61K36/428A61K36/481A61K36/484A61K36/54A61K36/57A61K36/65A61K36/71A61K36/714A61K36/79A61K36/804A61K36/884A61K36/8962A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 谢娟李正胜卢晶晶王志会黎利达宁杰杨一楠
Owner 贵州中医药大学第二附属医院
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