Applications of DCF1 gene knockout in preparation of drugs for alleviating Alzheimer's disease

Abstract

The present invention relates to applications of DCF1 gene knockout in preparation of drugs for alleviating Alzheimer's disease. According to the present invention, mainly wild type mice, dcf1 knockout mice and AD model mice are adopted as control, and Dcf1 gene knockout AD model mice are adopted as a research object; the thioflavine staining results of the mouse brain freezing slices show that the deposition of senile plaques can be reduced after DCF1 gene knockout; the observation results of the mouse spatial learning and memory ability from the ethology prove that the learning and memory ability of the mouse can be enhanced after DCF1 gene knockout; and the results show that the DCF1 gene knockout can alleviate Alzheimer's disease, and the gene target is provided for the development of the new AD treatment drug.

Description

technical field

[0001] The invention relates to the application of knocking out DCF1 gene in the preparation of medicine for alleviating Alzheimer's symptoms.

[0002] Background of the invention

[0003] AD (Alzheimer disease) is a common degenerative disease of the nervous system. Its clinical manifestation is mainly progressive dementia. , Reduced neurons. With the advent of an aging society, the incidence of AD continues to increase. According to statistics: there are more than 20 million AD patients in the world, and it is increasing at a rate of 4.6 million people every year. It has greatly reduced the quality of life and life expectancy of this population, and has caused serious social impact. Amyloid precursor protein (APP) can secrete β-amyloid 42 (amyloid-βprotein42, Aβ42) and β-amyloid 4 (0amyloid-βprotein 40, Aβ40) after being cleaved by proteolytic enzymes , and Aβ42 can lead to Alzheimer's disease (AD), and the occurrence of AD is mainly manifested by the de...

Images