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Medicine composition for treating or alleviating autoimmune diseases, complications thereof and/or nephritis, and applications of active components in the composition

A technology for autoimmune diseases and pharmaceutical compositions, which is applied in the field of pharmaceutical compositions for treating or slowing down autoimmune diseases and/or their complications and/or nephritis, and can solve problems such as recurrent disease in patients

Active Publication Date: 2017-08-01
IND TECH RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the mortality rate of lupus erythematosus has gradually decreased after the 1950s, patients still suffer from recurrent attacks of the disease

Method used

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  • Medicine composition for treating or alleviating autoimmune diseases, complications thereof and/or nephritis, and applications of active components in the composition
  • Medicine composition for treating or alleviating autoimmune diseases, complications thereof and/or nephritis, and applications of active components in the composition
  • Medicine composition for treating or alleviating autoimmune diseases, complications thereof and/or nephritis, and applications of active components in the composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0094] A.Materials and methods

[0095] 1. Method 1: Preparation of ethanol extract of medicinal materials

[0096] After the medicinal materials are washed or dried, they are coarsely pulverized. Add 500 g of medicinal material powder to 5 times the volume of 95% ethanol, and shake and extract at 25° C. for one week. The obtained extract was filtered to obtain the filtrate and its volume was quantified. Afterwards, 2 mL of the filtrate was sampled for high performance liquid chromatography (HPLC) and thin layer chromatography (TLC) analysis.

[0097] The rest of the filtrate was concentrated under reduced pressure to a volume of about 30 mL, then distributed into freeze-drying bottles and freeze-dried. The obtained freeze-dried product was the test drug (extraction rate: about 3.5%).

[0098] 2. Method 2: Use peripheral blood leukocyte (PBL) cell platform to screen drugs that inhibit IL-17 secretion

[0099] The blood of SD rats was obtained by blood collection from the s...

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Abstract

The invention provides a medicine composition for treating or alleviating autoimmune diseases, and / or complications thereof and / or nephritis. The medicine composition includes: an active component, which is an extract of a Rutaceae plant and is used for treating or alleviating the autoimmune diseases and / or nephritis, in effective dose, wherein the autoimmune diseases are selected from a group of: lupus erythematosus, psoriasis, psoriatic arthritis, ankylosing spondylitis, rheumatoid arthritis, juvenile idiopathic arthritis, Crohn's disease, and ulcerative colitis (UC).

Description

technical field [0001] The present invention relates to a pharmaceutical composition for treating or slowing down autoimmune diseases and / or its complications and / or nephritis and the application of its active ingredients. Background technique [0002] An autoimmune disease is a disease in which the body's own immune system attacks its own body's normal cells. In autoimmune patients, the immune system will produce antibodies against normal cells in the body (even various normal components in the cells), causing abnormal excessive inflammation or tissue damage, which will affect the health of the body. [0003] Autoimmune diseases such as lupus erythematosus usually affect multiple organs, including the brain, lungs and kidneys. The exact cause of lupus is unknown, but it may be related to genetics, hormones, environment and infection. Although the mortality rate of lupus erythematosus has gradually decreased after the 1950s, patients still suffer from recurrent attacks of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/75A61K31/395A61K31/403A61K31/37A61P37/02A61P13/12A61P17/00A61P19/02A61P19/08A61P1/00A61P1/04A61P31/10
CPCA61K31/37A61K31/395A61K31/403A61K36/75A61K31/366A61K31/404A61P1/00A61P1/04A61P13/12A61P17/00A61P19/02A61P19/08A61P31/10A61P37/02A61K31/4015
Inventor 黄国魁潘一红蔡莹霏吕亦晃吕居勋温淑芳郭宗铿邱淑娇
Owner IND TECH RES INST
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