Pelletizing method for sticky materials

A material and viscous technology, applied in the field of granulation of viscous materials, can solve the problems of high sugar content, high viscosity and long time consumption of materials, achieve uniform particles, reduce granulation cycle and improve granulation efficiency.

Active Publication Date: 2017-08-04
BEIJING GOLDENTEAM TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to propose a granulation method suitable for viscous materials, which can well solve the problems of easy collapse of the pot and long time consumption caused by the high sugar content and high viscosity of the material. high particle efficiency

Method used

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  • Pelletizing method for sticky materials

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Embodiment 1

[0034] Prepare 160kg of a certain granule, according to the formula requirements, take by weighing 44.5kg of extract, 5.6kg of amber powder, 23.7kg of dextrin, 23.8kg of β-cyclodextrin, and 62.4kg of sucrose powder. First add amber powder, dextrin, β-cyclodextrin, and sucrose powder to the material pot of the wet granulator, dry mix for 3 minutes, add extract, and granulate for 2 minutes. Make preliminary granules, then dry and pulverize to make 160kg of backfill powder.

[0035] Backfill powder 40kg, weigh again extract 33.4kg, amber powder 4.2kg, dextrin 17.8kg, β-cyclodextrin 17.8kg, sucrose powder 46.8kg, amber powder, dextrin, β-cyclodextrin, sucrose powder 1. Add the backfill powder to the material pot of the wet granulator, dry mix for 3 minutes, add the extract, and granulate for 2 minutes to produce 160kg of the granule. The particle size of the prepared granule is uniform and there is no phenomenon of stepping on the pot.

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Abstract

The invention discloses a pelletizing method for sticky materials. According to the pelletizing method disclosed by the invention, the materials in a formula are divided into sticky materials and non-sticky materials. The method comprises the following steps: firstly, mixing some non-sticky materials with some sticky materials, pelletizing for the first time, drying and crushing, thereby acquiring backfill powder, and then weighting the sticky materials, the non-sticky materials and the backfill powder on the basis of the secondary additive amount, mixing and pelletizing for the second time, thereby acquiring a to-be-pelletized product. The backfill powder is added in the pelletizing process, so that the sticky materials are prevented from collapsing in the pelletizing process and the prepared particles are uniform. The twice pelletizing can be used for increasing the material mixing efficiency, reducing the pelletizing period of the sticky materials and increasing the pelletizing efficiency. Besides, the backfill powder is prepared in advance according to the invention, so that the additive amount of the backfill powder, the sticky materials and the non-sticky materials in the secondary pelletizing process can be flexibly adjusted according to the yield requirement of the to-be-pelletized product, the pelletizing efficiency is further increased, the technology flexibility is high and the pelletizing method is suitable for large-scale production of the to-be-pelletized product.

Description

technical field [0001] The invention relates to the technical field of granulation methods, in particular to a granulation method suitable for viscous materials. Background technique [0002] The technical background related to the present invention will be described below, but these descriptions do not necessarily constitute the prior art of the present invention. [0003] At present, in the pharmaceutical industry, there are many granulation methods, but wet granulation is mainly used. The granules produced by the wet granulation process are mainly used for granules or tabletting; the characteristics of wet granulation are that the granulation time is short, the granules are irregular, and they need to be dried. In the pharmaceutical industry, some materials have high sugar content and high viscosity. The conventional wet granulation process cannot produce satisfactory granules, and what’s more, the pot will collapse, causing a lot of waste, which is not conducive to phar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16
CPCA61K9/1611A61K9/1623A61K9/1652A61K9/1682A61K9/1694
Inventor 邵天君
Owner BEIJING GOLDENTEAM TECH
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