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Preparation method of amphetamine

A technology of amphetamine and phenylacetone, which is applied in the field of preparation of amphetamine, and can solve the problems of low purity of amphetamine and unreasonable process setting.

Inactive Publication Date: 2017-08-04
王显权
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, at present, in the process of producing amphetamine by using phenylacetone, the process flow setting is unreasonable, resulting in a relatively low purity of the produced amphetamine, generally 80-85%.

Method used

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  • Preparation method of amphetamine
  • Preparation method of amphetamine

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation method of amphetamine, comprises the following steps:

[0024] a. Add ammonium formate into the enamel reaction kettle, and then feed hot oil at 150°C into the jacket of the enamel reaction kettle to make the ammonium formate a molten liquid;

[0025] b. Heat the ammonium formate melt to 173°C, then drop phenylacetone to form a mixed solution, the molar ratio between phenylacetone and ammonium formate is 1:1.2;

[0026] c. The ammonium formate and phenylacetone in the mixed solution were reacted at 170°C for 3.5 hours to obtain a reaction solution. During the reaction process of ammonium formate and phenylacetone, the evaporated substance was condensed and returned to the mixture through a plastic coil; then cooled The oil reduces the temperature of the reaction solution to 40°C;

[0027] d, adding concentration to the reaction solution after cooling is 10% hydrochloric acid to make the reaction solution neutral;

[0028] e. Heat the reaction solution ...

Embodiment 2

[0033] The preparation method of amphetamine, comprises the following steps:

[0034] a. Add ammonium formate into the enamel reaction kettle, and then feed hot oil at 130°C into the jacket of the enamel reaction kettle to make the ammonium formate a molten liquid;

[0035] b. Heat the ammonium formate melt to 175°C, then drop phenylacetone to form a mixed solution, the molar ratio between phenylacetone and ammonium formate is 1:1.2;

[0036] c. The ammonium formate and phenylacetone in the mixed solution reacted at 175°C for 3 hours to obtain a reaction solution. During the reaction process of ammonium formate and phenylacetone, the evaporated substance was condensed and returned to the mixture through a plastic coil; Make the temperature of reaction solution drop to 40 ℃;

[0037] d, adding concentration to the reaction solution after cooling is 10% hydrochloric acid to make the reaction solution neutral;

[0038] e. Heat the reaction solution after adding hydrochloric aci...

Embodiment 3

[0043] The preparation method of amphetamine, comprises the following steps:

[0044] a. Add ammonium formate to the enamel reaction kettle, and then feed hot oil at 140°C into the jacket of the enamel reaction kettle to make the ammonium formate a molten liquid;

[0045] b. Heat the ammonium formate melt to 170°C, then add phenylacetone dropwise to form a mixed solution, and the molar ratio between phenylacetone and ammonium formate is 1:1.2;

[0046] c. The ammonium formate and phenylacetone in the mixed solution were reacted at 173°C for 3.5 hours to obtain a reaction solution. During the reaction process of ammonium formate and phenylacetone, the evaporated material was condensed and returned to the mixture through a plastic coil; then cooled The oil reduces the temperature of the reaction solution to 40°C;

[0047] d, adding concentration to the reaction solution after cooling is 10% hydrochloric acid to make the reaction solution neutral;

[0048] e. Heat the reaction ...

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Abstract

The invention discloses a preparation method of amphetamine in the technical field of preparation of amphetamine. The method includes steps a, adding and heating ammonium formate in an enamel reaction kettle and making it become melted liquid; b, dropwise adding phenylacetone in ammonium formate melted liquid to form a mixed fluid, and heating to 170-175 DEG C; c, reacting ammonium formate and phenylacetone in the mixed fluid for 3-3.5 h to obtain a reaction fluid; then cooling to 40 DEG C; d, adding hydrochloric acid to the cooled reaction fluid and making the reaction fluid become neutral; e, heating and reacting the reaction fluid for 3-3.5 h to obtain a secondary reaction fluid; then cooling to 40 DEG C; f, adding sodium hydroxide solution with concentration of 20% in the secondary reaction fluid to obtain alkali fluid with pH value of 11; g, statically placing and layering the alkali fluid, and extracting amphetamine in the lower salt fluid by trichloro ethylene to obtain extraction fluid, and then mixing the upper oil fluid to obtain the combining fluid; h, distilling the combining fluid; after evaporating trichloro ethylene, depressurizing and distilling the combining fluid to obtain amphetamine. The amphetamine produced by the scheme has high purity.

Description

technical field [0001] The invention relates to the technical field of preparation of amphetamine, in particular to a preparation method of amphetamine. Background technique [0002] Amphetamine, also known as phenylethylpropylamine, α-methylphenethylamine, etc., has a molecular formula of C9H13N and a relative molecular weight of 135.21. It is a colorless oily liquid with pungent taste and weak smell. Amphetamines cause profound psychoactive effects, including increased alertness, initiative, and confidence, euphoria, decreased fatigue, increased speech, and increased ability to concentrate. Amphetamines can reduce appetite when taken before meals, so they are widely used to assist food restriction for weight loss. Pilots, truck drivers, and soldiers often use it for missions that require prolonged wakefulness. Amphetamines also play a major role in the treatment of ADHD, as the drug calms children after a day, allowing them to concentrate. Amphetamines are also used to...

Claims

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Application Information

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IPC IPC(8): C07C209/22C07C211/27
CPCC07C209/22C07C211/27
Inventor 王显权
Owner 王显权
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