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A flexible hollow mesoporous organosilica nanocapsule material and its preparation method

An organic silicon oxide, hollow mesoporous technology, applied in the field of nanomaterials, can solve the problems of lack of flexibility, non-deformation, poor stability, etc., and achieve the effects of low price, low equipment requirements, and high specific surface area.

Active Publication Date: 2020-11-17
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Technical problem to be solved: In order to overcome the deficiencies in the prior art, this application proposes a flexible hollow mesoporous organosilica nanocapsule and its preparation method. This kind of nanocapsule has flexible and deformable characteristics, which is conducive to passing through tumor blood vessels , its mesoporous structure can efficiently load anti-tumor drugs, and solve technical problems such as poor stability, lack of flexibility and non-deformability in the prior art

Method used

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  • A flexible hollow mesoporous organosilica nanocapsule material and its preparation method
  • A flexible hollow mesoporous organosilica nanocapsule material and its preparation method
  • A flexible hollow mesoporous organosilica nanocapsule material and its preparation method

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Embodiment 1

[0033] Such as figure 1 with Figure 5 As shown, a flexible hollow mesoporous organic silica nanocapsule material, the flexible hollow mesoporous organic silica nanocapsule material is a flexible organic silica particle with a hollow structure, the organic silica particle is composed of a surfactant, Ammonia, ethanol, water, tetraethylorthosilicate, bridging organic silicon oxide source, alkali solution and concentrated hydrochloric acid, the shell of the organic silica particles has mesoporous pores, the flexible hollow mesoporous organic oxide The preparation method of silicon nanocapsule material includes the following steps:

[0034] The first step: Dissolve 0.16 g cetyltrimethylammonium bromide in a mixed solution of 75ml water, 30ml ethanol and 1ml ammonia. The ammonia contains NH 3 The mass percentage concentration is 25%. Mix 0.25 ml of tetraethylorthosilicate and 0.1 ml of bis[γ-(triethoxysilyl)propyl]tetrasulfide at 35℃ and 300 rpm stirring conditions. , Reaction for 2...

Embodiment 2

[0039] Such as figure 2 with image 3 As shown, a flexible hollow mesoporous organic silica nanocapsule material, the flexible hollow mesoporous organic silica nanocapsule material is a flexible organic silica particle with a hollow structure, the organic silica particle is composed of a surfactant, Ammonia, ethanol, water, tetraethylorthosilicate, bridging organic silicon oxide source, alkali solution and concentrated hydrochloric acid, the shell of the organic silica particles has mesoporous pores, the flexible hollow mesoporous organic oxide The preparation method of silicon nanocapsule material includes the following steps:

[0040] The first step: Dissolve 0.16 g cetyltrimethylammonium bromide in a mixed solution of 75ml water, 30ml ethanol and 1ml ammonia. The ammonia contains NH 3 The mass percentage concentration of bismuth is 25%, and 0.25 ml of tetramethyl orthosilicate and 0.05 ml of 1,2-bis(triethoxysilyl)benzene are reacted for 24 h at 35°C and 300 rpm stirring condi...

Embodiment 3

[0045] Such as Figure 4 As shown, a flexible hollow mesoporous organic silica nanocapsule material, the flexible hollow mesoporous organic silica nanocapsule material is a flexible organic silica particle with a hollow structure, the organic silica particle is composed of a surfactant, Ammonia, ethanol, water, tetraethylorthosilicate, bridging organic silicon oxide source, alkali solution and concentrated hydrochloric acid, the shell of the organic silica particles has mesoporous pores, the flexible hollow mesoporous organic oxide The preparation method of silicon nanocapsule material includes the following steps:

[0046] The first step: Dissolve 0.16 g cetyltrimethylammonium bromide in a mixed solution of 75ml water, 30ml ethanol and 1ml ammonia. The ammonia contains NH 3 The mass percentage concentration is 25%, and 0.25 ml of tetraethyl orthosilicate and 0.25 ml of 1,2-bis(triethoxysilyl)ethane are reacted for 24 h at 35°C and 300 rpm stirring conditions As the reaction prog...

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Abstract

The invention discloses a flexible hollow mesoporous organic silicon oxide nanocapsule and a preparation method. The flexible hollow mesoporous organic silicon oxide nanocapsule has the characteristic of flexibility, is prepared from organic silicon oxide as a framework component, and is in a spheroid shape; the spheroid is provided with a hollow structure; a shell is provided with a mesoporous channel. The preparation method of the flexible hollow mesoporous organic silicon oxide nanocapsule comprises the steps of dissolving a surface active agent into an ammonia-containing mixed solution of alcohol and water; adding tetraethoxysilane and an organic silicon oxide precursor under a heating and stirring condition; after reacting for a period of time, etching obtained solid organic silicon oxide in an alkaline solution, and forming the flexible hollow mesoporous organic silicon oxide nanocapsule; finally removing the surface active agent to obtain the flexible hollow mesoporous organic silicon oxide nanocapsule. The flexible hollow nanocapsule provided by the invention has great application potentiality in the fields such as drug delivery.

Description

Technical field [0001] The invention belongs to the technical field of nanomaterials, and specifically relates to a flexible hollow mesoporous organic silicon oxide nanocapsule material and a preparation method thereof. Background technique [0002] After being injected intravenously into the blood, nanomedicine must pass through the tumor blood vessel wall to reach the tumor cells in order to function. Malignant tumors have large vascular wall gaps, poor structural integrity, lack of lymphatic drainage, and higher permeability than normal tissue vessels. Taking advantage of the characteristic that the blood vessel threshold of malignant tumors is larger than that of normal tissues, drug carriers can be selectively delivered to tumor tissues. However, tumor blood vessels have pores of various sizes (ie, permeability thresholds), and it is difficult for probes with large sizes to pass through tumor blood vessels; while probes with small sizes are rapidly metabolized by the liver ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/24A61P35/00
CPCA61K47/24
Inventor 苏晓丹滕兆刚马晓波
Owner NANJING UNIV OF POSTS & TELECOMM