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Thymus dependent lymphocyte antigen epitope peptide sequences of hepatitis B virus antigen

A technology of hepatitis B virus, lymphocytes, applied in the field of medical immunology and infectious diseases

Inactive Publication Date: 2017-08-08
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, HLA-A*0101, A*0301, A*3001, A*3101, A*3201, A*3303 and A*6801 with relatively high frequencies in the Chinese population are rarely reported.

Method used

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  • Thymus dependent lymphocyte antigen epitope peptide sequences of hepatitis B virus antigen
  • Thymus dependent lymphocyte antigen epitope peptide sequences of hepatitis B virus antigen
  • Thymus dependent lymphocyte antigen epitope peptide sequences of hepatitis B virus antigen

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Experimental program
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Embodiment Construction

[0026]The HLA-A molecule-restricted HBV specific antigen peptide of the present invention comprises the following steps:

[0027] 1. Obtain the amino acid sequence of HBV protein by searching the GeneBank database and the UniProt global protein resource database, and select the most studied protein sequence. ).

[0028] 2. Using six commonly used epitope prediction databases SYFPEITHI, BIMAS, SVMHC, IEDB, NETMHC and EPIJEN (http: / / www.syfpeithi.de / , http: / / www-bimas.cit.nih.gov / molbio / hla_bind / , ttp: / / www.sbc.su.se / ~pierre / svmhc / , http: / / www.immunepitope.org / tools.do / , http: / / www.cbs.dtu.dk / services / NetMHC / , http: / / www.ddg-pharmfac.net / epijen / EpiJen / EpiJen.htm / ) the amino acids of the above-mentioned hepatitis B virus antigens HBsAg (P03138), HBcAg (P03146), HBpol (P03156) and HBx (P03165) The affinity and spatial conformation analysis of the sequence and each of the HLA-A molecules such as HLA-A*0101, A*0301, A*3001, A*3101, A*3201, A*3303 and A*6801 , predict and screen...

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Abstract

The invention discloses a group of thymus dependent lymphocyte antigen epitope peptide sequences of a hepatitis B virus antigen. Molecule-limited antigen peptides, such as HLA-A*0101, A*0301, A*3001, A*3101, A*3201, A*3303, and A*6801 can be specifically combined with cytotoxicity thymus dependent lymphocytes, and then the activation, proliferation and differentiation of the cytotoxicity thymus dependent lymphocytes are promoted, so as to perform the immunity effect action of resisting the hepatitis B virus. The antigen peptides can be used for preparing vaccines for treating and preventing the infection of hepatitis B virus, and also can be used for preparing detection reagents for detecting the specific cytotoxicity thymus dependent lymphocytes of the hepatitis B virus, and the potential application value is realized in the prevention, treatment and diagnosis of the hepatitis B virus.

Description

technical field [0001] The invention belongs to the fields of medical immunology and infectious diseases, and relates to the antigenic epitope peptide sequences of various hepatitis B viruses. Background technique [0002] Hepatitis B virus (HBV) infection is one of the most common infectious diseases, which seriously endangers human health. According to statistics from the World Health Organization in July 2015, it is estimated that 1 / 3 of the world's population has been infected with HBV, and about 248 million HBV carriers may develop liver cirrhosis and primary hepatocellular carcinoma in the later stage. About 780,000 HBV-infected patients die each year due to disease progression to cirrhosis, liver failure, or liver cancer. Epidemiological surveys show that about 800 million people in mainland China have been infected with HBV, and the carrier rate of hepatitis B surface antigen (HBsAg) is as high as 10.34%. half of the population. In addition, my country is also a b...

Claims

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Application Information

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IPC IPC(8): C07K14/02G01N33/576G01N33/569A61K39/29A61P1/16A61P31/20
CPCA61K39/12A61K2039/53C07K14/005C12N2730/10122C12N2730/10134G01N33/56977G01N33/5761G01N33/5762G01N33/5764
Inventor 沈传来
Owner SOUTHEAST UNIV
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