Preparations for external use on the skin containing bupivacaine or a pharmaceutically acceptable salt thereof
A technology of bupivacaine and external preparations, which is applied in the field of pharmaceutical preparations, and can solve the problems of reducing the peeling strength of patches, inconvenient industrial production, and reduced stability of patches.
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Embodiment 1
[0024]
[0025] Preparation method: add the prescribed amount of bupivacaine into an appropriate amount of ethyl acetate, and mix to obtain the main drug mixture; mix the prescribed amount of colloid evenly, add the main drug solution into the colloid, stir, and mix evenly; The prepared paste is evenly spread on the anti-adhesive layer, covered with a backing layer, and cut to the required size after the ethyl acetate volatilizes.
Embodiment 2
[0027]
[0028] Note: The volume ratio of ethyl acetate and ethanol is 1:1 to prepare a mixed solution.
[0029] Preparation method: add the prescribed amount of terpene resin into a certain amount of mixed solution of ethyl acetate and ethanol, and stir evenly; add the prescribed amount of bupivacaine into a certain amount of mixed solution of ethyl acetate and ethanol, and stir evenly , to obtain the main drug solution; add the mixed solution obtained above into a container with colloid, continue to stir, and after stirring evenly, apply the prepared paste evenly on the anti-adhesive layer, cover the backing layer, and wait for ethyl acetate After the ester and ethanol volatilize, it is cut to the required size.
Embodiment 3
[0031]
[0032] Note: The volume ratio of ethyl acetate and ethanol is 1:1 to prepare a mixed solution.
[0033] Preparation method: add the prescribed amount of terpene resin into a certain amount of mixed solution of ethyl acetate and ethanol, and stir evenly; add the prescribed amount of bupivacaine into a certain amount of mixed solution of ethyl acetate and ethanol, and stir evenly , to obtain the main drug solution; add the mixed solution obtained above into a container with colloid, and continue to stir. After stirring evenly, apply the prepared paste evenly on the anti-adhesive layer, cover the backing layer, and wait for ethyl acetate After the ester and ethanol volatilize, it is cut to the required size.
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