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Application of hydroxypropyl methylcellulose in nursing care of upper gastrointestinal mucosal injury

A technology of hydroxypropyl methyl cellulose and sodium carboxymethyl cellulose is applied in the application field of hydroxypropyl methyl cellulose in the nursing of upper gastrointestinal mucosal damage, which can solve the problem of large dosage and no local damage It can solve the problems of drug use in mucosal sites, slow onset of effect, etc., to achieve the effects of long duration, good film-forming effect and strong adhesion.

Active Publication Date: 2021-02-26
HEFEI JIUYAN MEDICINE TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, anti-inflammatory drugs are mostly used in the treatment of esophageal mucosal injuries. They are administered through the gastrointestinal tract, injection or intravenous infusion, and are basically administered systemically. The dosage is large, and the drug cannot be directly applied to the locally damaged mucosa, and the onset of effect is slow.

Method used

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  • Application of hydroxypropyl methylcellulose in nursing care of upper gastrointestinal mucosal injury
  • Application of hydroxypropyl methylcellulose in nursing care of upper gastrointestinal mucosal injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Weigh 1 g of hydroxypropyl methylcellulose and 1000 g of purified water.

[0033] Add hydroxypropyl methylcellulose into purified water with a total water consumption of 40% under stirring, and continue stirring until the swelling is completely transparent;

[0034] Add the rest of the purified water and stir for 0.5h, that is.

Embodiment 2

[0036] Weigh 15 grams of hydroxypropyl methylcellulose and 1000 grams of purified water.

[0037] Add hydroxypropyl methylcellulose into purified water with a total water consumption of 40% under stirring, and continue stirring until the swelling is completely transparent;

[0038] Add the rest of the purified water and stir for 0.5h, that is.

Embodiment 3

[0040] Weigh 28 grams of hydroxypropyl methylcellulose and 1000 grams of purified water.

[0041] Add hydroxypropyl methylcellulose into purified water with a total water consumption of 40% under stirring, and continue stirring until the swelling is completely transparent;

[0042] Add the rest of the purified water and stir for 0.5h, that is.

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Abstract

The invention discloses the application of hydroxypropyl methylcellulose in the care of upper gastrointestinal mucosal injury. The hydroxypropyl methylcellulose can also be a composition containing hydroxypropyl methylcellulose, which includes the following components in parts by weight Composition: 1-28 parts by weight of hydroxypropyl methylcellulose, 1000 parts by weight of purified water; the preparation method includes: adding hydroxypropyl methylcellulose to purified water with a total water consumption of 40% under stirring, and continuing to stir until Swell completely into a transparent solution; add the remaining purified water and stir until it is completely dissolved; the hydroxypropyl methylcellulose of the present invention and the composition containing hydroxypropyl methylcellulose have the effect of producing a film in the upper digestive tract , the resulting film is mucoadhesive, making the film action sustainable.

Description

technical field [0001] The invention relates to the application of a substance with special efficacy, in particular to the application of hydroxypropyl methylcellulose in the care of upper digestive tract mucosal injury. Background technique [0002] The upper gastrointestinal tract consists of the oral cavity, pharynx, esophagus, stomach, and duodenum. Mouth: Consists of lips, cheeks, palate, teeth, tongue and oral glands. After the oral cavity is stimulated by food, the glands in the oral cavity secrete saliva, and the chewed food is mixed with saliva, and the amylase in saliva can partially decompose carbohydrates through the esophagus through the lubricating effect of saliva. Pharynx: is the common passage of the respiratory and digestive tracts. The pharynx can be divided into three parts, the nasopharynx (part), the oropharynx (part), and the hypopharynx (part) according to the passages with the nasal cavity, oral cavity and larynx. The main function of the pharynx ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/717A61K31/724A61P1/04A61P31/04A61P29/00
CPCA61K31/717A61K31/724A61P1/02A61K9/08A61K47/38A61P1/04A61K47/26A61K47/12A61K47/36A61K47/42A61K47/02A61K47/14
Inventor 高宇卜允利
Owner HEFEI JIUYAN MEDICINE TECH DEV
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