Magnetic targeting dual-drug-carrying delivery system and preparation method thereof

A dual-loaded drug and magnetic targeting technology, which is applied in the field of biomedical materials, can solve the problems of lack of targeting, drug resistance, and influence on curative effect, and achieve good magnetic targeting, improve therapeutic index, and improve therapeutic effect.

Active Publication Date: 2017-08-29
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the inorganic drug carrier mainly composed of mesoporous silica is mainly loaded with a single drug, which is prone to drug resistance and affects the curative effect, and mesoporous silica as a drug carrier lacks targeting
Secondly, inorganic drug carriers have always been a difficult problem to overcome in high drug loading

Method used

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  • Magnetic targeting dual-drug-carrying delivery system and preparation method thereof
  • Magnetic targeting dual-drug-carrying delivery system and preparation method thereof
  • Magnetic targeting dual-drug-carrying delivery system and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The preparation of mesoporous ferric oxide hollow nanoparticles (HMFNs), the specific steps are as follows:

[0048] Weigh 2mmol ferric chloride hexahydrate, 4mmol trisodium citrate, 6mmol urea, 0.3g polyacrylamide, 0.2g polyethylene glycol 2000 into 40ml deionized water, stir to dissolve completely; transfer the obtained clear solution to In a high-pressure reactor, react at a temperature of 200° C. for 12 h, cool down to room temperature naturally, centrifuge, wash with water and ethanol twice, and vacuum-dry at room temperature overnight to obtain HMFNs.

[0049] The transmission electron microscopy results of the HMFNs prepared in this example are shown in figure 2 , see particle size test results image 3 , nitrogen adsorption and desorption and pore size distribution results are shown in Figure 4 .

[0050] Depend on figure 2 with image 3 The results show that the average particle size of HMFNs is 300nm, the particle size distribution is narrow, and the p...

Embodiment 2

[0052] The preparation of mesoporous ferric oxide hollow nanoparticles (HMFNs), the specific steps are as follows:

[0053] Weigh 2mmol ferric chloride hexahydrate, 4mmol trisodium citrate, 8mmol urea, 0.4g polyacrylamide, 0.4g polyethylene glycol 1000 into 40ml deionized water, stir to dissolve completely; transfer the obtained clear solution to In a high-pressure reactor, react at a temperature of 180° C. for 18 h, naturally cool to room temperature, centrifuge, wash with water and ethanol twice, and vacuum dry at room temperature overnight to obtain HMFNs.

Embodiment 3

[0055] The preparation of mesoporous ferric oxide hollow nanoparticles (HMFNs), the specific steps are as follows:

[0056] Weigh 2mmol ferric chloride hexahydrate, 4mmol trisodium citrate, 10mmol urea, 0.6g polyacrylamide, 0.6g polyethylene glycol 4000 and add them to 40ml deionized water, stir to dissolve completely; transfer the obtained clear solution to In a high-pressure reactor, react at a temperature of 220° C. for 24 h, naturally cool to room temperature, centrifuge, wash with water and ethanol twice, and vacuum-dry at room temperature overnight to obtain HMFNs.

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Abstract

The invention relates to a magnetic targeting dual-drug-carrying delivery system and a preparation method thereof, and belongs to the technical field of biomedical materials. The magnetic targeting dual-drug-carrying delivery system is prepared by the following steps: 1, preparing hollow and mesoporous ferritenanoparticles (HMFNs) through a one-step hydrothermal method; 2, injecting hydrophobic drug molecules into an HMFNs cavity through a vacuum injection and dynamic crystallization combination method or a supercritical fluid technological measure; 3, adding the hydrophobic drug molecule-carrying HMFNs into a hydrophilic drug solution, and performing treatment, thus preparing the hydrophobic drug and hydrophilic drug dual-drug-carrying delivery system. The HMFNs provided by the invention are relatively high in saturation magnetization and can enter a targeting part under the guide action of an outer magnetic field. Furthermore, the HMFNs are further high in biocompatibility, and the inner cavity structures of the HMFNs are favorable for loading of hydrophobic drugs; shells of the HMFNs are rich in hydroxyl groups and are favorable for adsorption of hydrophilic drugs; meanwhile, the variety of the hydrophobic drugs and the hydrophilic drugs can be selected according to a requirement; the magnetic targeting dual-drug-carrying delivery system has good application prospect.

Description

technical field [0001] The invention relates to a magnetic targeting dual-loaded drug delivery system and a preparation method thereof, in particular to a hydrophobic drug and hydrophilic drug dual-loaded drug delivery system and a preparation method thereof, belonging to the technical field of biomedical materials. Background technique [0002] In recent years, chronic non-communicable diseases such as cardiovascular and cerebrovascular diseases, malignant tumors, and diabetes in my country have continued to rise and become younger. These diseases have become the main cause of death and heavy medical burden for urban and rural residents in my country. Major diseases such as tuberculosis, hepatitis, and cancer still lack effective prevention and treatment methods, and the drugs used to treat these diseases generally have the following limitations: (1) lack of targeting, (2) multidrug resistance. [0003] Targeted drug delivery system, or targeted drug delivery system, was bo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/60A61K41/00A61K31/496A61K31/337A61K31/704A61K31/133A61K31/4409
CPCA61K9/0009A61K31/133A61K31/337A61K31/4409A61K31/496A61K31/704A61K41/00A61K2300/00
Inventor 戴红莲徐超李泳兴
Owner WUHAN UNIV OF TECH
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