Application of fecal microbial transplantation in treating Parkinson's disease

Abstract

The invention discloses application of fecal microbial transplantation in treating Parkinson's disease, belongs to the technical field of medical neuropharmacology and relates to potential application of fecal bacteria flora in drug for clinical treatment of the Parkinson's disease. A Parkinson's disease animal model is built, various research methods like ethology, immunology and biochemical indexes are applied comprehensively, and experiments prove that the drug can improve dyskinesia symptoms of mice of the Parkinson's disease model and reduce degeneration of substantia nigra pars compacta dopaminergic neurons. The fecal bacteria flora is extensive in raw material source and good in effect, thereby having certain development value and prospect in clinical application.

Description

technical field [0001] The invention relates to the application of fecal bacteria transplantation in treating Parkinson's disease, and belongs to the technical field of medical neuropharmacology. Background technique [0002] Parkinson's disease (PD) is the most common degenerative disease of the motor nervous system, the main clinical manifestations are: resting tremor, slowness of movement, unsteady standing and postural reflex disorder. The main lesions in the brain of patients with Parkinson's disease are the substantia nigra and striatum. The death and reduction of dopaminergic neurons in the substantia nigra compacta is the direct cause of the decrease in dopamine projected to the striatum. As the second largest neurodegenerative disease after Alzheimer's disease, the incidence and prevalence of Parkinson's disease increase sharply with age, and the prevalence rate reaches 1% among the elderly over 60 years old. People over the age of 85 account for 5%-6%. At present, ...

AI Technical Summary

Problems solved by technology

Among them, drug treatment is mostly symptomatic treatment, which can temporarily relieve symptoms, but cannot inhibit or delay the progress of the disease, while surgical treatment has certain indications, and the cost is relatively high

Different from drug therapy, fecal microbiota transplantation (Fecal Microbiota Transplantation, FMT), as a special organ transplantation and therapy that can rebuild intestinal flora, has attracted clinical attention. Currently, it is mainly used in recurrent Clostridium difficile infection, inflammatory bowel disease, Irritable bowel syndrome and other intestinal diseases, as well as metabolic diseases and autism, have the advantages of high cure rate and few adverse reactions. There are very few reports on the treatment of PD, and its great potential remains to be discovered.

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