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Isoliquiritigenin-cyclodextrin or cyclodextrin derivative inclusion complex, composition, preparation method and novel application

A technology of isoliquiritigenin and cyclodextrin, which is applied in the application field of deep processing of isoliquiritigenin, can solve the problems of poor absorption, poor solubility of isoliquiritigenin, poor solubility, etc.

Active Publication Date: 2017-09-15
宁夏蓝博思化学技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Isoliquiritigenin has the pharmacological activity of eliminating free radicals and anti-oxidation, but its solubility in water is poor, and its absorption is poor when taken. Therefore, it is necessary to solve the problem of poor solubility of isoliquiritigenin and poor absorption by the human body
[0008] There is no report about the preparation technology of isoliquiritigenin-cyclodextrin or cyclodextrin derivative inclusion compound, and the research on its inclusion compound and composition for anti-exercise fatigue

Method used

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  • Isoliquiritigenin-cyclodextrin or cyclodextrin derivative inclusion complex, composition, preparation method and novel application
  • Isoliquiritigenin-cyclodextrin or cyclodextrin derivative inclusion complex, composition, preparation method and novel application
  • Isoliquiritigenin-cyclodextrin or cyclodextrin derivative inclusion complex, composition, preparation method and novel application

Examples

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Effect test

Embodiment 1

[0030] Example 1: Preparation method of isoliquiritigenin-β-cyclodextrin inclusion compound

[0031] Take 1mmol of β-cyclodextrin, add 60g of water to dissolve, add 1mmol of isoliquiritigenin while stirring at room temperature, continue to stir, so that the β-cyclodextrin and isoliquiritigenin are completely reacted, after the reaction is completed, a solution is obtained, and The above solution was filtered with a microporous membrane, and the filtrate was pre-frozen in a -80°C refrigerator for 4 hours, and then dried overnight at -80°C with a freeze dryer to obtain a solid isoliquiritigenin-β-cyclodextrin inclusion compound.

Embodiment 2

[0032] Example 2: Preparation method of isoliquiritigenin-β-cyclodextrin inclusion compound

[0033] Take 10mmol of β-cyclodextrin, add 600g of water to dissolve, add 1mmol of isoliquiritigenin while stirring at room temperature, continue to stir, so that the β-cyclodextrin and isoliquiritigenin are completely reacted, after the reaction is completed, a solution is obtained, and The above solution was filtered with a microporous membrane, and the filtrate was pre-frozen in a -80°C refrigerator for 4 hours, and then dried overnight at -80°C with a freeze dryer to obtain a solid isoliquiritigenin-β-cyclodextrin inclusion compound.

Embodiment 3

[0034] Example 3: Preparation method of isoliquiritigenin-hydroxypropyl-β-cyclodextrin inclusion compound

[0035] Take 1mmol of hydroxypropyl-β-cyclodextrin, add 10g of water to dissolve, add 1mmol of isoliquiritigenin while stirring at room temperature, and continue stirring to completely react the hydroxypropyl-β-cyclodextrin and isoliquiritigenin, After the reaction is completed, a solution is obtained, and the above solution is filtered with a microporous membrane, and the filtrate is pre-frozen in a refrigerator at -80°C for 4 hours, and then dried overnight at -80°C with a freeze dryer to obtain solid isoliquiritigenin-hydroxypropyl-β - Cyclodextrin inclusion complexes.

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Abstract

The invention relates to an isoliquiritigenin-cyclodextrin or cyclodextrin derivative inclusion complex, composition, preparation method and novel application, application of the isoliquiritigenin-cyclodextrin or cyclodextrin derivative inclusion complex in preparing a drug for improving or treating anti-exercise fatigue and a medicinal composition. In the process of researching the isoliquiritigenin-cyclodextrin or cyclodextrin derivative inclusion complex, by establishing an animal model and detecting variation of hepatic glycogen, blood lactic acid and urea nitrogen in a experimental mice sample, the effect of the isoliquiritigenin for resisting the anti-exercise fatigue is proved, and the anti-exercise fatigue-resistant medicinal composition is prepared.

Description

technical field [0001] The invention belongs to the application technical field of isoliquiritigenin deep processing, and in particular relates to an inclusion compound of isoliquiritigenin-cyclodextrin or cyclodextrin derivatives, a composition, a preparation method and a new application. Background technique [0002] Exercise-induced fatigue is an eternal theme in the research of sports medicine and exercise physiology. Regarding the formation mechanism of exercise-induced fatigue, various hypotheses have been put forward, such as the theory of energy material depletion, the theory of free radical damage, the theory of neurotransmitters, the theory of lactic acid accumulation and the theory of Ca 2+ Steady-state anomaly theory, etc. [0003] The theory of exhaustion of energy substances proposes that energy substances include various glycogen, ATP, creatine phosphate, etc. During short-term high-intensity exercise, the body will use a large amount of energy substances suc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K31/12A61P39/00
CPCA61K31/12
Inventor 黄少云戈胡蓉罗生霞孙涛黄青魏世杰王志忠
Owner 宁夏蓝博思化学技术有限公司
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