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Retinoic acid compound, and preparation method, intermediate and application thereof

A compound and enantiomer technology, applied in the field of retinoic acid compounds, can solve the problem of poor tumor cell inhibition rate and other problems

Active Publication Date: 2017-09-19
SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The problem to be solved by the present invention is to provide a kind of retinoic acid compound, its preparation method, intermediate and application in order to overcome the defects such as tazarotene's poor tumor cell inhibitory rate, and the inhibitory effect of the compound on tumor cells better rate

Method used

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  • Retinoic acid compound, and preparation method, intermediate and application thereof
  • Retinoic acid compound, and preparation method, intermediate and application thereof
  • Retinoic acid compound, and preparation method, intermediate and application thereof

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Abstract

The invention discloses a retinoic acid compound, and a preparation method, an intermediate and application thereof. The retinoic acid compound I provided by the invention has better inhibition ratio on tumor cells. (The formula (I) is shown in the description).

Description

A kind of retinoic acid compound, its preparation method, intermediate and application technical field The invention relates to a retinoic acid compound, its preparation method, intermediate and application. Background technique Tazarotene is a retinol drug with RAR subtype selectivity (J Am AcadDermatol.1997, 37, S12.), mainly used for local epithelial hyperplasia (psoriasis, psoriasis, acne etc.) treatment. Tazarotene exists as a prodrug of the ethyl ester. The drug enters the body and undergoes enzymatic metabolism to obtain the carboxyl-type active metabolite Tazarotenic acid, which can highly selectively interact with RARβ and RARγ receptors, and also has a certain effect on RARβ, but has a weak effect on RXR. Contents of the invention The problem to be solved by the present invention is to provide a kind of retinoic acid compound, its preparation method, intermediate and application in order to overcome the defects such as tazarotene’s poor tumor cell inhibitory...

Claims

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Application Information

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IPC IPC(8): C07D335/06C07D409/06C07C69/84C07C69/76C07C63/74C07D239/28C07C229/56C07D213/85C07D213/79C07C65/19C07C233/54A61K31/382A61K31/506A61K31/235A61K31/192A61K31/196A61P35/00A61P35/02A61P17/10A61P17/06A61P15/00
CPCC07C63/74C07C65/19C07C69/76C07C69/84C07C229/56C07C233/54C07D213/79C07D213/85C07D239/28C07D335/06C07D409/06A61P35/00A61P35/02C07D241/24C07C67/343C07C2602/10A61P35/04C07C63/70C07C69/78C07D213/84C07D409/10
Inventor 曹鑫俞飚汪宁陈俊威
Owner SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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