Retinoic acid compound, and preparation method, intermediate and application thereof
A compound and enantiomer technology, applied in the field of retinoic acid compounds, can solve the problem of poor tumor cell inhibition rate and other problems
Active Publication Date: 2017-09-19
SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI +1
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The problem to be solved by the present invention is to provide a kind of retinoic acid compound, its preparation method, intermediate and application...
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The invention discloses a retinoic acid compound, and a preparation method, an intermediate and application thereof. The retinoic acid compound I provided by the invention has better inhibition ratio on tumor cells. (The formula (I) is shown in the description).
Description
A kind of retinoic acid compound, its preparation method, intermediate and application technical field The invention relates to a retinoic acid compound, its preparation method, intermediate and application. Background technique Tazarotene is a retinol drug with RAR subtype selectivity (J Am AcadDermatol.1997, 37, S12.), mainly used for local epithelial hyperplasia (psoriasis, psoriasis, acne etc.) treatment. Tazarotene exists as a prodrug of the ethyl ester. The drug enters the body and undergoes enzymatic metabolism to obtain the carboxyl-type active metabolite Tazarotenic acid, which can highly selectively interact with RARβ and RARγ receptors, and also has a certain effect on RARβ, but has a weak effect on RXR. Contents of the invention The problem to be solved by the present invention is to provide a kind of retinoic acid compound, its preparation method, intermediate and application in order to overcome the defects such as tazarotene’s poor tumor cell inhibitory...
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Login to view more IPC IPC(8): C07D335/06C07D409/06C07C69/84C07C69/76C07C63/74C07D239/28C07C229/56C07D213/85C07D213/79C07C65/19C07C233/54A61K31/382A61K31/506A61K31/235A61K31/192A61K31/196A61P35/00A61P35/02A61P17/10A61P17/06A61P15/00
CPCC07C63/74C07C65/19C07C69/76C07C69/84C07C229/56C07C233/54C07D213/79C07D213/85C07D239/28C07D335/06C07D409/06A61P35/00A61P35/02C07D241/24C07C67/343C07C2602/10A61P35/04C07C63/70C07C69/78C07D213/84C07D409/10
Inventor 曹鑫俞飚汪宁陈俊威
Owner SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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