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Preparation method of nikethamide injection

A technology for the preparation of injections and nicothamide, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of not being fast and effective, so as to ensure curative effect and promote poisonous The effect of excretion

Inactive Publication Date: 2017-09-22
北京市永康药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But, in the prior art, for the preparation of nikethamide injection, also do not have a kind of fast, effective, safe method

Method used

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  • Preparation method of nikethamide injection

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preparation example Construction

[0023] Such as figure 1 As shown, the nikethamide injection preparation method provided by the embodiments of the present invention comprises the following steps:

[0024] Step 1. Add the weighed nicothamide into a first liquid mixing tank, and add water for injection to the first liquid mixing tank through a pipeline with stirring function located in the first liquid mixing tank tank, during the process of adding water for injection into the first liquid mixing tank, add medicinal charcoal to the first liquid mixing tank, and the pipeline rotates to mix the water for injection with the nicothamide and the The medicinal charcoal is mixed and stirred, and when the water for injection is added, it is left to stand for 10 to 20 minutes for later use. The mass volume ratio of the nicothamide to the water for injection is 1:2 to 1:3. Accounting for 0.1% to 0.2% of the mixed volume of the nicothamide and water for injection;

[0025] Wherein, the specific arrangement of the pipeli...

Embodiment 1

[0037]Step 1. Add the weighed nicothamide into a first liquid mixing tank, and add water for injection to the first liquid mixing tank through a pipeline with stirring function located in the first liquid mixing tank tank, during the process of adding water for injection into the first liquid mixing tank, add medicinal charcoal to the first liquid mixing tank, and the pipeline rotates to mix the water for injection with the nicothamide and the Medicinal charcoal was mixed and stirred, and when the water for injection was added, it was left to stand for 10 minutes for later use. The mass-to-volume ratio of the nicothamide to the water for injection was 1:2, and the medicinal charcoal accounted for the nikothamide 0.1% of the mixed volume of rice and water for injection;

[0038] Step 2. Pass the thick dosing solution in the first dosing tank obtained in step 1 through a 3 μm titanium rod filter for coarse decarburization, and the thick dosing solution after decarburization ente...

Embodiment 2

[0045] Step 1. Add the weighed nicothamide into a first liquid mixing tank, and add water for injection to the first liquid mixing tank through a pipeline with stirring function located in the first liquid mixing tank tank, during the process of adding water for injection into the first liquid mixing tank, add medicinal charcoal to the first liquid mixing tank, and the pipeline rotates to mix the water for injection with the nicothamide and the Medicinal charcoal was mixed and stirred, and when the water for injection was added, it was left to stand for 20 minutes for later use. The mass-to-volume ratio of the nicothamide to the water for injection was 1:3, and the medicinal charcoal accounted for the nikothamide 0.2% of the mixed volume of rice and water for injection;

[0046] Step 2. Pass the thick dosing solution in the first dosing tank obtained in step 1 through a 3 μm titanium rod filter for coarse decarburization, and the thick dosing solution after decarburization ent...

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Abstract

The invention discloses a preparation method of a nikethamide injection. The preparation method comprises the following steps: adding nikethamide into a first liquid blending tank, adding water for injection into the first liquid blending tank through a pipeline positioned inside the first liquid blending tank and having a stirring function, adding medicinal carbon into the first liquid blending tank in the adding process of the water for injection, and rotating the pipeline to mix and stir the water for injection, the nikethamide and the medicinal carbon; coarsely filtering the obtained concentrated blended solution for carbon removal by using a titanium rod filter, then enabling the carbon-removed concentrated blended solution to enter a second liquid blending tank, and adding a certain amount of glucose and a certain amount of water for injection into the second liquid blending tank; testing the PH of the obtained dilute blended solution, and controlling the PH value of the dilute blended solution to be 5.8-7.2; performing circulating filtration on the dilute blended solution till a clarified state by using a plate-and-frame filter press with a polytetrafluoroethylene hydrophilic filter membrane. By the preparation method, a formula of the nikethamide injection is improved, and the nikethamide injection has a good therapeutic effect on central respiratory depression as well as respiratory depression caused by a variety of reasons; the preparation method is high in efficiency, sanitary and safe.

Description

technical field [0001] The invention belongs to the field of preparation of medical liquid, in particular to a preparation method of nikethamide injection. Background technique [0002] Nicothamide is used for central respiratory and circulatory failure, poisoning of anesthetics and other central depressants. Nicothamide injection is a colorless clear liquid that can be used for subcutaneous injection, intramuscular injection or intravenous injection for central respiratory depression and respiratory depression caused by various reasons. However, in the prior art, there is no fast, effective and safe method for the preparation of nicothamide injection. Contents of the invention [0003] In order to overcome the deficiencies in the prior art, the present invention provides a preparation method of nikethamide injection, which improves the formula of nikethamide injection, and is effective for central respiratory depression and various causes. The respiratory depression has...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/455A61K47/26A61P11/00A61P25/00
CPCA61K9/0019A61K9/08A61K31/455A61K47/26
Inventor 高树庄左钰李玉会
Owner 北京市永康药业有限公司
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