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Nanoemulsions

An oil-in-water emulsion and emulsifier technology, applied in the field of nanoemulsions, can solve the problems of difficult hydrophobic properties of active ingredients and the like

Inactive Publication Date: 2017-09-26
UNIV OF LIVERPOOL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In particular, buccal delivery is often desired but can be difficult due to the hydrophobic nature of most active ingredients

Method used

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  • Nanoemulsions
  • Nanoemulsions
  • Nanoemulsions

Examples

Experimental program
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Embodiment

[0075] Part 1: Preparation of branched polymers (containing dodecyl moieties, PolyOEGMA DP80 chains linked using EGDMA), their use to prepare nanoemulsions for incorporation into drugs and safety and efficacy studies of these nanoemulsions

[0076] Polymer preparation

[0077] Polymers for stabilizing nanoemulsions can be fabricated using atom transfer radical polymerization (ATRP), a controlled polymerization method that allows the definition of a specific degree of polymerization (DP). One example of a water-soluble polymer according to the invention is based on PolyOEGMA DP80.

[0078] By DP80, it is meant that there are about 80 monomer units (OEGMA) per polymer chain. These linear chains were branched together by using EGDMA as branching agent.

[0079]First, the amount of monomer was weighed in a round bottom flask (OEGMA, Mw 300). The balance was tared and then the appropriate amount of EGDMA branched was added such that the molar ratio to monomer was 0.95. A dodecy...

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Abstract

An oil-in-water emulsion comprises an emulsifier which is a non-gelled branched polymer (e.g. a branched vinyl polymer), wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. This is useful in, for example, facilitating the carrying of hydrophobic materials within aqueous systems, to enhance oral drug delivery. The oil-in-water emulsion may be prepared by mixing an oil phase with an aqueous phase in the presence of an emulsifier, wherein said emulsifier is a non-gelled branched polymer, wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. The oil phase may comprise a further solvent which is miscible with the oil, said solvent being allowed to evaporate to produce the final emulsion.

Description

technical field [0001] The present invention relates to components, methods of manufacture and uses of nanoemulsions and nanoemulsion compositions. Nanoemulsions are particularly useful for oral drug delivery. Background technique [0002] Drug delivery is quite an active and challenging field. New methods of delivering known active ingredients can bring considerable benefits, such as minimizing the amount of drug needed to treat a particular condition, ensuring that the drug reaches the desired location, improving convenience, controlling the release profile, and improving patient compliance. In particular, oral delivery is often desired but can be difficult due to the hydrophobic nature of most active ingredients. [0003] Many researchers have sought ways to deal with this problem and in particular the poor water solubility of drugs. [0004] Encapsulation can be used to isolate and deliver active materials. For example, WO 2013 / 024307 discloses the use of amphiphilic...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/10A61K47/34C08F220/20C09K23/00
CPCA61K9/1075A61K47/10A61K47/34C08F220/20C08F220/282C09K23/34A61K31/513A61K31/536C08F220/286C08F222/102A61K9/0053A61K9/107A61K9/1641C08F2438/01
Inventor 史蒂夫·兰纳德安德鲁·欧文詹姆斯·霍布森尼尔·利普特罗特皮埃尔·尚邦
Owner UNIV OF LIVERPOOL