Crystallization reaction system of tenofovir production line

Abstract

A crystallization reaction system of a tenofovir production line comprises a low-temperature reaction kettle and a distilled type reaction kettle, wherein the low-temperature reaction kettle comprises a low-temperature reaction kettle body, a low-temperature control device, a stirring device and a centrifugal type solid-liquid separating device; a feeding opening is formed in the top of the low-temperature reaction kettle body; a discharging opening is formed in the bottom of the low-temperature reaction kettle body; the low-temperature control device comprises an alcohol box, an electronic control valve and a rotary atomizing sprayer; and the alcohol box is fixedly mounted on the top of the low-temperature reaction kettle body. The crystallization reaction system of the tenofovir production line is reasonable in structural design, the low-temperature reaction kettle drives fan type stirring blades by an electric sliding table, the stirring blades automatically rotate in a vertical moving process due to a fluid principle, and therefore, the stirring purpose is achieved; the power of a motor is reduced, the heating amount is further reduced, and the crystallization reaction efficiency is high; and by the distilled type reaction kettle, distillation reaction of diethyl tenofovir as a semi-finished product of tenofovir can be efficiently finished, the distillation efficiency is high, the purity of the product is also high, and the practical value is high.

Description

technical field [0001] The invention relates to the technical field of chemical equipment, in particular to a crystal precipitation reaction system of a tenofovir production line. Background technique [0002] Tenofovir (Compound I), also known as Tenofovir, Chinese full name: (R is used in the secondary precipitation reaction kettle of Tenofovir production line)-9-(2-phosphomethoxypropyl)-adeno Purine is used in the secondary precipitation reaction of tenofovir production line, which is an AIDS antiviral drug. Tenofovir is also a better AIDS antiviral drug. Tenofofumarate fumarate is used in the tenofovir production line The key intermediate of vir dipivoxil (used in the secondary precipitation reactor II of tenofovir production line for the secondary precipitation reactor of tenofovir production line). In the tenofovir production line, it is necessary to stir the primary reaction solution with brine to precipitate HPA product crystals. The existing low-temperature reactor...

AI Technical Summary

Problems solved by technology

In the tenofovir production line, it is necessary to stir the primary reaction solution with brine to precipitate HPA product crystals. The existing low-temperature reactor uses a high-power motor for stirring, which not only wastes energy, but also increases additional heat and hinders the precipitation. reaction

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