Drug relocation method based on gene mutation and gene expression

A gene expression and gene expression profiling technology, applied in the field of data mining, can solve the problem of low accuracy of positioning results, and achieve the effect of improving the accuracy.

Active Publication Date: 2017-10-24
XIDIAN UNIV
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Problems solved by technology

[0012] The purpose of the present invention is to overcome the defects in the above-mentioned prior art, and propose a drug repositioning method based on gene mutation and gene expression, which is used to solve the technical problem of low accuracy of positioning results in the prior art

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  • Drug relocation method based on gene mutation and gene expression
  • Drug relocation method based on gene mutation and gene expression
  • Drug relocation method based on gene mutation and gene expression

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Embodiment Construction

[0034] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments.

[0035] This embodiment takes liver cancer as an example.

[0036] refer to figure 1 . A drug repositioning method based on gene mutation and gene expression, comprising the following steps:

[0037] Step 1) processing SNP mutation data: count the mutation frequency of each gene in all disease state samples in the SNP mutation data, and obtain the mutation frequency data of all genes;

[0038] Step 2) Process the gene expression data, and calculate the change value of each gene expression and its statistical significance:

[0039] (2a) Obtain the cancer patient sample set and the normal person sample set: use the Barcode code provided by TCGA to identify the sample type of the gene expression data in TCGA, specifically: the digital code of the fourth part of the Barcode code of the sample is from 01 to 09 The interval is a cancer pa...

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Abstract

The invention provides a drug relocation method based on gene mutation and gene expression. The method is used for solving the technical problem that in the prior art, a location result is low in accuracy. The method comprises the implementation steps that SNP mutation data is processed to obtain mutation frequency data of all genes; gene expression data is processed to obtain standard gene expression matrix data, and all gene expression change values and statistical significance values are calculated; secondary classification is performed on the mutation frequency data of all the genes in the SNP mutation data and the genes in the standard gene expression matrix data; correlation values of diseases and all drugs are acquired; absolute values of the correlation values of the diseases and all the drugs are calculated, and all the drugs are ordered according to a descending rule of the absolute values to obtain rankings of all the drugs; and candidate drugs with potential treatment effects on the diseases are acquired. The method can be used for predicting the candidate drugs with potential treatment effects on cancers.

Description

technical field [0001] The invention belongs to the technical field of data mining and relates to a drug repositioning method, in particular to a drug repositioning method based on gene mutation and gene expression, which can be used to predict candidate drugs with potential therapeutic effects on cancer. Background technique [0002] Usually the research and development of a new drug is very costly and time-consuming, and it is also accompanied by high risk costs. Take the development of a new drug as an example: it takes about 15 years from the proposal of research to the launch of the drug, and costs about 800-1000 million US dollars, but only about 10% of the drug can be successfully applied to the clinic. Such huge research and development expenses and high research and development risks lead to the need for a new method to reduce the cost of drug research and development. The cost of drug research and development is the fundamental reason for the emergence of the rese...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/24G06F19/18G06F19/20
CPCG16B20/00G16B25/00G16B40/00
Inventor 鱼亮许凤丹
Owner XIDIAN UNIV
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