Security control and efficiency optimization system for cornea/sclera crosslinking technology

Abstract

The invention provides a security control and efficiency optimization system for a cornea / sclera crosslinking technology. The system comprises a security threshold control system and an efficiency optimization system, wherein the security threshold control system carries out refrigeration regulation according to a real-time and non-contact tissue temperature measured value; and the efficiency optimization system carries out humidity and / or oxygen concentration regulation according to a real-time humidity and / or oxygen concentration measured value. The system provided by the invention has the advantages that overtreatment is prevented while enhanced photochemical crosslinking reaction is guaranteed; meanwhile, an efficiency optimization method and an automatic control system are provided on the basis of a photochemical mechanism enhanced reaction principle, and treatment effect is enhanced by controlling oxygen concentration and humidity of a treatment space and increasing photochemical reaction crosslinking intensity, so that the system provided by the invention can enhance the cornea crosslinking effect and also can reduce side effect of reaction and has the characteristics of strengthening crosslinking effect by controlling the oxygen concentration and humidity of an environment and carrying out local tissue cooling by virtue of temperature monitoring refrigeration equipment automatically starting humidifying.

Description

technical field [0001] The present invention relates to the safe use control and performance optimization of cornea and / or sclera cross-linking technology, in particular, to the safety control and performance optimization system and method of cornea / sclera cross-linking technology, especially to photothermal damage-based and photochemical mechanism-based An automatic control system and method for strengthening the reaction principle, the system and method are especially suitable for clinical and laboratory applications of various cornea and / or sclera cross-linking techniques based on photochemical principles. Cornea / sclera refers to the cornea and / or sclera. Background technique [0002] Photochemical cross-linking is a method in which photosensitive substances produce photochemical reactions under the action of an exciting light source, causing collagen molecules to form covalent cross-links between collagen fibers to connect. This method can strengthen tissue in cornea or ...

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Problems solved by technology

According to our unpublished experimental data (attached figure 1 ), compared with the control group (Control group), under high concentration oxygen environment (O 2 group) can increase the cross-linking efficiency (corneal stiffness) by 2.5 times and there is a significant statistical difference, while under the normal air environment (Air group) can enhance the corneal stiffness by 1.97 times and there is a statistical difference, and under the hypoxic environment (N 2 group) Photochemotherapy did not have any effect on enhancing corneal stiffness (not statistically significant)

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