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Tranexamic acid-induced rat hypercoagulation state animal model and its construction method

A technology of animal model and construction method, which is applied in the field of experimental zoology, can solve the problems of availability, non-availability, and affecting animal eating, etc., and achieve the effect of simple operation and high success rate of the model

Active Publication Date: 2021-02-12
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its disadvantage is that the zygomatic arch of the animal is removed, which affects the animal's eating, and is not conducive to long-term observation. This method needs to be improved (Liu Xiaoguang, Xu Lina. A rat brain that can evaluate thrombolytic and antithrombotic drugs Model of Arterial Thrombosis. Acta Pharmaceutica Sinica. 1995,30; 662-667; Zhang Yuzhen. Protective effect of Ginkgo biloba extract (EGB) on regional cerebral ischemia and jugular vein thrombosis in rats. Pharmacology. 1998,33(12): 901-905)
The current animal model of thrombosis cannot meet the needs of this type of research, and does not meet the conditions required for this type of research
There are currently no established off-the-shelf model systems available for animal models of hypercoagulable states

Method used

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  • Tranexamic acid-induced rat hypercoagulation state animal model and its construction method
  • Tranexamic acid-induced rat hypercoagulation state animal model and its construction method
  • Tranexamic acid-induced rat hypercoagulation state animal model and its construction method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1, construct rat hypercoagulation state animal model

[0049] 1. Experimental materials and reagents

[0050] (1) Experimental animals

[0051]SPF-grade male Wistar rats, 180-220 g, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., and the experiment began after one week of adaptive feeding under standard conditions.

[0052] (2) Reagents

[0053] The reagents used are shown in Table 1.

[0054] Table 1 Reagents used to construct rat hypercoagulable state animal model

[0055]

[0056] (3) Instruments and consumables

[0057] The instruments and consumable reagents used are listed in Table 2.

[0058] Table 2 The instruments and consumables used in the establishment of animal models of rat hypercoagulation state

[0059]

[0060] 2. Experimental steps

[0061] Twenty male wistar rats were randomly divided into two groups, 10 in each group, and weighed. Rats in the experimental group were given tranexamic acid (3...

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Abstract

The invention discloses an animal model in a tranexamic acid induced hyper-coagulation state and a building method thereof. The building method is characterized in that a rat is gavaged for two times with tranexamic acid, and then the animal model in the tranexamic acid induced hyper-coagulation state can be formed during 2-12 hours; the operation is simple; the success rate of the model is high; and the hyper-coagulation state lasts a long time. The building method is simple to operate, and high in success rate of the model, and the hyper-coagulation state lasts a long time. With the adoption of the building method, the tranexamic acid based rat animal model in the hyper-coagulation state is successfully built; a foundation is provided to the study on related rat hyper-coagulation state; and a novel rate hyper-coagulation state animal model method is provided.

Description

technical field [0001] The invention relates to a rat hypercoagulation state animal model induced by tranexamic acid and a construction method thereof, belonging to the field of experimental zoology. Background technique [0002] The hypercoagulable state, also known as the pre-thrombotic state, refers to a state in which the body exhibits an increased tendency to coagulate blood. It is generally believed that the emergence of hypercoagulable state is related to the serious abnormality of the coagulation function of the coagulation system, and the reasons are complex and diverse. There is also a view that hypercoagulable states can be divided into hereditary hypercoagulable states and acquired hypercoagulable states. Hereditary hypercoagulability is due to specific genetic mutations that lead to thrombosis, the onset age is relatively low, and the site of thrombosis is relatively special. In terms of general pathological distribution, the range of acquired hypercoagulable ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/195A61P7/04A01K67/02
CPCA01K67/02A61K31/195
Inventor 井健杜震环高友鹤何碧溪
Owner BEIJING NORMAL UNIVERSITY
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