Synthetic method and application of pyridyl-benzimidazolyl polynuclear complexes
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A benzimidazole and synthetic method technology, applied in the field of complex synthesis, can solve the problems of less research on polynuclear metal complexes, etc., and achieve the effect of simple synthetic method and low price
Active Publication Date: 2017-11-03
HENAN UNIV OF URBAN CONSTR
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On the other hand, compared with the antitumor activity of mononuclear complexes, t
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Embodiment 1
[0028] The synthetic method of pyridine-benzimidazole base polynuclear complex comprises the steps:
[0029] S1, synthesis of ligand (ppbm)
[0030] S11. Weigh 0.7150g of 2-pyridinebenzimidazole into a 100mL three-neck flask, add 30mL of acetone that has been dehydrated, and then add 0.6mL of PEG-400, 0.9250g of K 2 CO 3 , 0.0925g KI was stirred at room temperature for 30min. Weigh 0.5100g of 3-chloromethylpyridine hydrochloride in a 25mL Erlenmeyer flask, add 10mL of acetone that has been dewatered, stir at room temperature for 30min, then add the acetone solution in which 3-chloromethylpyridine hydrochloride is dissolved to Three-necked flask, reflux at 60°C for 12 hours, and filter while hot to get the filtrate;
[0031] S12. Slowly add the filtrate to the pure water dropwise at the ratio of v / v=1:40, stop when the solution is about to turn red, and stand at room temperature for 2-3 days to observe the precipitation of brown needle-like crystals, filter, After drying at...
Embodiment 2
[0037] The synthetic method of pyridine-benzimidazole base polynuclear complex comprises the steps:
[0038] S1, synthesis of ligand (ppbm)
[0039] S11. Weigh 0.7150g of 2-pyridinebenzimidazole into a 100mL three-neck flask, add 30mL of acetone that has been dehydrated, and then add 0.6mL of PEG-400, 0.9250g of K 2 CO 3 , 0.0925g KI was stirred at room temperature for 30min. Weigh 0.5100g of 3-chloromethylpyridine hydrochloride in a 25mL Erlenmeyer flask, add 10mL of acetone that has been dewatered, stir at room temperature for 30min, then add the acetone solution in which 3-chloromethylpyridine hydrochloride is dissolved to Three-necked flask, reflux at 60°C for 12 hours, and filter while hot to get the filtrate;
[0040] S12. Slowly add the filtrate to the pure water dropwise at the ratio of v / v=1:40, stop when the solution is about to turn red, and stand at room temperature for 2-3 days to observe the precipitation of brown needle-like crystals, filter, Dry at room tem...
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Abstract
The invention discloses a synthetic method and application of pyridyl-benzimidazolyl polynuclear complexes. The synthetic method comprises the following steps: S1, synthesis of ligand (ppbm); and S2, synthesis of Cu<3>(ppbm)<2>(SO<4>)<3> or synthesis of Co<2>(ppbm)<2>(NO<3>)<4>. The two complexes synthesized in the invention can be used for preparation of antitumor drugs. According to the invention, a benzimidazole derivative with biological activity is used as the ligand, and a trinuclear copper complex and a binuclear cobalt complex are constructed; the novel structural characteristics of the two complexes determine that the two complexes have different antitumor spectra compared with other metal drugs; copper and cobalt are essential life elements for metabolism of human beings and are low in price; and the synthetic method for the complexes is simple and easily practicable, and the prepared complexes have obvious inhibitory effect on tumor cell proliferation.
Description
technical field [0001] The invention relates to the field of compound synthesis, in particular to a synthesis method and application of a pyridine-benzimidazole-based polynuclear complex. Background technique [0002] Since the anticancer drug cisplatin has been used in clinic, it has been considered as one of the most effective tumor chemotherapy drugs. However, many defects such as strong toxic side effects and drug resistance limit the clinical application efficiency of cisplatin and various classic platinum anticancer drugs to a certain extent. While developing new platinum-based antitumor drugs, researchers have also begun to explore non-platinum compounds with anti-tumor activity. Partial transition metal complexes have the advantages of cheapness, low toxicity, target molecule targeting, etc., and the anti-tumor mechanism and reactivity are different from the reported noble metal compounds, which have aroused extensive interest of researchers. Among them, Cu(II) and...
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