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Long-duration blood cell stabilizer

A blood cell and stabilizer technology, applied in the field of cells, can solve the problems of difficulty in carrying out experiments and insufficient 72-hour stabilization period, and achieve the effect of prolonging the stabilization time and preventing platelet aggregation

Inactive Publication Date: 2017-11-10
CHENGDU ZHIA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In major disaster medical assistance or medical assistance work in remote areas, the 72-hour stabilization period is often not enough
In addition, in some blood tests that take a long time, due to the need for consistent blood sources, it is difficult for ordinary stabilizers to provide such a long stabilization time, making it difficult to carry out corresponding tests

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Disodium cromolyn 25 μmol / L

[0030] Poloxamer 0.13 mg / L

[0031] β-cyclodextrin 125 μmol / L

[0032] Ecodoine 11.5 μmol / L

[0033] Triflusal 23 μmol / L

[0034] Potassium dichromate 0.07%

[0035] Trehalose 160 μmol / L

[0036] The potassium dichromate is a mass percent concentration.

Embodiment 2

[0039] Disodium cromolyn 20μmol / L

[0040] Poloxamer 0.12 mg / L

[0041] β-cyclodextrin 120μmol / L

[0042] Ecodoine 10μmol / L

[0043] Triflusal 20 μmol / L

[0044] Potassium dichromate 0.07%

[0045] Trehalose 80 μmol / L

[0046] The potassium dichromate is a mass percent concentration.

Embodiment 3

[0049] Disodium cromolyn 40 μmol / L

[0050] Poloxamer 0.16 mg / L

[0051] β-cyclodextrin 140 μmol / L

[0052] Ecodoine 12 μmol / L

[0053] Triflusal 25μmol / L

[0054] Potassium dichromate 0.07%

[0055] Trehalose 200 μmol / L

[0056] Described potassium dichromate is the mass percent concentration.

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Abstract

The invention provides a long-duration blood cell stabilizer. The stabilizer is composed of 20-40 mumol / L disodium cromoglycate, 0.12-0.16 mg / L poloxamer, 120-140 mumol / L beta-cyclodextrin, 10-12 mumol / L ectoin, 20-25 mumol / L triflusal, 0.07% potassium dichromate and 80-200 mumol / L trehalose, wherein the potassium dichromate is in a mass percent concentration. According to the blood cell stabilizer, it is very effective to stabilize blood cells in blood and prevent platelet aggregation, the blood cells can be provided with a stabilizing effect for at least 120 hours, and compared with existing products, the stabilizing duration is prolonged by at least 48 hours.

Description

technical field [0001] The invention belongs to the technical field of cells, and in particular relates to a long-term blood cell stabilizer. Background technique [0002] In related blood research and clinical research, the stability of blood cells is very important. Generally speaking, after whole blood is collected, common blood anticoagulants can only provide blood stabilization within 6 hours. As an alternative reagent, formaldehyde fixative (such as Kryofix) is also often used, but formaldehyde is toxic and easy to volatilize, and there are certain quality control difficulties and safety hazards. [0003] In recent years, some new blood cell stabilizers have appeared one after another, which mainly stabilize the cell membrane through β-cyclodextrin, disodium cromoglycate and potassium dichromate. Glycosides to further provide blood stabilizing effects. However, the stability time provided by existing stabilizers is still very limited, and the most common time known ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N1/02
CPCA01N1/0226
Inventor 向桂香
Owner CHENGDU ZHIA TECH CO LTD