Application of chimonanthus plant anti-helicobacter pylori

Abstract

The invention discloses application of chimonanthus plant anti-helicobacter pylori, and particularly relates to chimonanthus plants and application of extracts of the chimonanthus plants in preparing drugs for preventing / treating related diseases caused by helicobacter pylori. The chimonanthus plants comprise chimonanthus salicifolius, chimonanthus zhejiangensis or chimonanthus nitens; the extracts comprise a water extract, an alcohol extract, a water vapor distillation extract and a supercritical extract.

Description

technical field [0001] The present invention specifically relates to the application of wintersweet plants and their extracts in the preparation of medicines for the prevention / treatment of related diseases caused by Helicobacter pylori. field. Background technique [0002] Wintersweet (Chimonanthus salicifolius S.Y.Hu), Zhejiang wintersweet (Chimonanthuszhejiangensis M.C.Liu) or mountain wintersweet (Chimonanthus nitens Oliv.) are traditional medicines of the She people. The herbal tea that has been taken for nearly a thousand years is its dried leaves, which have been used to treat and prevent colds since the Northern Song Dynasty. Modern research has progressed again. Among them, the granule preparation prepared from the extract of wintersweet has a good effect on treating / preventing colds and has been sold in the market; wax plum and Zhejiang wintersweet have been included in the "Zhejiang traditional Chinese medicine processing in 2005 and 2015". The main ingredient i...

AI Technical Summary

Problems solved by technology

Supercritical extraction technology based on CO2 has the advantages of low temperature, rapidity, high efficiency, no pollution, and high purity of the extract. It is a new technology for the separation and purification of modern natural medicines, and is more suitable for the research and application of volatile oil. Therefore, the present invention extracts willow leaves The effective substance of wintersweet is the starting point. For the first time, the process route and influencing parameters of adding or not adding entraining agent and adding entrainer first and then the design and experiment of the system, in-depth, comparison, master the influence and law of different processes and parameters on the product , isolated nearly 20 new extracts, and used them to screen against Helicobacter pylori. For the first time, several active extracts were found, especially effective against drug-resistant strains. The results have not been reported so far.

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