Urine detection test paper for reflecting human fatigue degree, and preparation method thereof

A technology for detecting test paper and fatigue degree, which is applied in the field of medical detection, can solve the problems of low detection sensitivity and affect the accuracy of detection results, and achieve the effects of good biocompatibility, large specific surface area, and high detection sensitivity

Inactive Publication Date: 2017-11-10
ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the detection sensitivity of the existing urine protein detection test paper is low, especially when the urine protein content is very small, the discoloration is not obvious, which seriously affects the accuracy of the detection results

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 2

[0030] Take by weighing 70g chitosan and be dissolved in 6.5L mass concentration and be in the glacial acetic acid solution of 1.00%, turn on ultrasonic wave and make chitosan dissolve completely, add 50gN-hydroxyl succinimide, continue to turn on ultrasonic wave to mix, then add 60g1-( 3-Dimethylaminopropyl)-3-ethylcarbodiimide was stirred until it was completely dissolved, then 38g of arginine was added, and the stirring was continued for 24 hours to obtain a reaction solution, which was subjected to dialysis treatment. Before the dialysis treatment, the dialysis bag was immersed in Sufficiently absorb water in distilled water, then put the reaction solution into a dialysis bag and dialyze with distilled water for 2 days. Pre-freeze for half an hour under the temperature condition of 6° C. to -3° C., and then transfer to a freeze dryer to freeze-dry to obtain arginine-modified chitosan.

[0031] Weigh 15g of nano titanium dioxide powder and dissolve it in deionized water to ...

preparation Embodiment 3

[0033] Take by weighing 60g chitosan and be dissolved in 5.0L mass concentration and be in the glacial acetic acid solution of 1.00%, turn on ultrasonic wave and make chitosan dissolve completely, add 40gN-hydroxyl succinimide, continue to turn on ultrasonic wave to mix, then add 46g1-( 3-Dimethylaminopropyl)-3-ethylcarbodiimide was stirred until it was completely dissolved, then 25g of arginine was added, and the stirring was continued for 22 hours to obtain a reaction solution, which was subjected to dialysis treatment. Before dialysis treatment, the dialysis bag was immersed in Sufficiently absorb water in distilled water, then put the reaction solution into a dialysis bag and dialyze with distilled water for 2 days. Pre-freeze for half an hour under the temperature condition of 6° C. to -3° C., and then transfer to a freeze dryer to freeze-dry to obtain arginine-modified chitosan.

[0034] Weigh 15g of nano-titanium dioxide powder and dissolve it in deionized water to obtain...

Embodiment 1

[0035] The crystal form structure of the nano-titanium dioxide used in embodiment one, embodiment two and embodiment three is anatase type, and particle size is 20nm~50nm, and the preparation method of this nano-titanium dioxide is as follows: add titanium tetrachloride to anhydrous Stir in ethanol at 60°C for 8h to prepare a precursor solution, mix the precursor solution with hydrochloric acid and zinc salt, and obtain H in the mixed solution + / Ti=4, Zn / Ti=0.45, reflux the mixed solution at 100°C for 20h to obtain a precipitate, filter it, wash it with ethanol, dry and pulverize it, transfer it to a muffle furnace to raise the temperature at a rate of 5°C per minute After storing at 650° C. for 3 hours, cooling to obtain anatase-type nano-titanium dioxide.

[0036] Example 4 of Preparation of Urine Test Paper

[0037] Weigh 0.35g of water-soluble polythiophene, 0.45g of chloroauric acid tetrahydrate, 16g of sodium dihydrogen phosphate and 2g of sodium hydroxide, dissolve th...

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Abstract

The invention relates to the technical field of medical detection, particularly to a urine detection test paper for reflecting the human fatigue degree, and a preparation method thereof, wherein the urine detection test paper contains thiol protease, sodium dihydrogen phosphate, water-soluble polythiophene, chloroauric acid tetrahydrate, sodium hydroxide and polyvinyl alcohol, and the surface of the urine detection test paper is coated with a chitosan/titanium dioxide composite film. The preparation method comprises: immersing filtration paper in the mixed solution of a solution A and a solution B, and covering the surface of the filtration paper with a chitosan/titanium dioxide composite film, wherein the solution A contains water-soluble polythiophene, chloroauric acid tetrahydrate, sodium dihydrogen phosphate and sodium hydroxide, and the solution B contains polyvinyl alcohol and thiol protease. According to the present invention, the prepared urine detection test paper has advantages of strong hydrophilicity, convenient operation and high detection sensitivity, and can adsorb and permeate urine protein.

Description

technical field [0001] The invention relates to the technical field of medical detection, in particular to a urine detection test paper that reflects the degree of human fatigue and a preparation method thereof. Background technique [0002] Fatigue is a state of natural exhaustion of one or some organs or even the strength of the whole body due to changes in the physical and psychological state of the laborer during the labor process. Fatigue is a physiological phenomenon as well as a psychological phenomenon. In essence, it is a normal physiological protection mechanism of the body. From a biomedical theory, labor is a process of energy consumption. When this process continues to a certain extent, the central nervous system will have an inhibitory effect. After the fatigue of the central nervous system, it is the fatigue of the motor nervous system, which reflects the sensitivity of the movement. Reduced, work efficiency decreased. Fatigue is a subjective experience of f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/78G01N33/68
CPCG01N21/78G01N33/68
Inventor 糜漫天易龙张乾勇朱晓辉张婷
Owner ARMY MEDICAL UNIV
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