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Method for effectively reducing glycyrrhizic acid and glycyrrhetinic acid in licorice flavonoid compound

A technology of licorice flavonoids and glycyrrhetinic acid, which is applied in the field of licorice flavonoids, can solve the problems of reducing the content of active ingredients, affecting product qualification, and unsatisfactory treatment effects, so as to achieve the effect of reducing content and improving product qualification rate

Inactive Publication Date: 2017-12-01
新疆全泰兴药业科技有限公司
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Problems solved by technology

[0004] The existing methods have unsatisfactory treatment effects, because the active ingredient molecules of licorice flavonoids are similar to glycyrrhetinic acid, and their properties are similar, which reduces the content of glycyrrhetinic acid and the content of active ingredients, which affects product qualification.

Method used

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Embodiment Construction

[0011] The following clearly and completely describes the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0012] A method for reducing glycyrrhizic acid and glycyrrhetinic acid in licorice flavonoids with energy efficiency, comprising the following steps: adding 4-5% salts containing divalent metal ions to the alkali suspension, stirring for 60 minutes, and counting the precipitation, Discard the precipitate, collect the supernatant, add appropriate amount of hydrochloric acid, adjust the pH value to 5, precipitate, centrifuge, discard the supernatant, wash the precipitate with water until the pH value is 7, centrifuge, discard the super...

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Abstract

The invention discloses a method for effectively reducing glycyrrhizic acid and glycyrrhetinic acid in a licorice flavonoid compound. The method comprises the following steps that 4%-5% of salt containing bivalent metal ions is added into an alkali mixed suspension, stirring is conducted for 60 minutes, precipitation is conducted along with timing, precipitates are removed, and supernate is collected; appropriate hydrochloric acid is added, and the PH value is adjusted to be 5; sediment is conducted, and centrifugal separation is conducted; supernate is removed, precipitates are taken and washed till the PH value of the precipitates is 7; and centrifugal separation is conducted, supernate is removed, precipitates are taken and dried, and thus a finished product is obtained. The content of the glycyrrhetinic acid is decreased but the content of effective components is not decreased, therefore, the product qualification rate is greatly increased, and the qualification rate is increased from 30% to 95%.

Description

technical field [0001] The invention relates to the technical field of licorice flavonoids, in particular to a method for energy-efficiently reducing glycyrrhizic acid and glycyrrhetinic acid in licorice flavonoids. Background technique [0002] Licorice flavonoids have anti-tumor, anti-inflammation, anti-oxidation, anti-arrhythmia, liver protection and other effects. When extracting licorice flavonoids from licorice or licorice residue, some glycyrrhizic acid and glycyrrhetinic acid are often extracted. Glycyrrhizic acid and glycyrrhetinic acid may cause side effects such as water and sodium retention after being ingested by the human body. Therefore, glycyrrhizic acid (licorice hypoxic acid) is often listed as the limited inspection part of licorice flavonoids. [0003] Diatomaceous earth is a siliceous rock, a biogenic siliceous sedimentary rock composed primarily of the remains of ancient diatoms. Its chemical composition is mainly SiO2, and contains a small amount of ...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61P35/00A61P29/00A61P39/06A61P9/06A61P1/16A61K125/00
CPCA61K36/484
Inventor 王海峰周寒利赵向英苗田清罗恒磊
Owner 新疆全泰兴药业科技有限公司
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