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Metal-organic framework material for detecting tryptophan, and preparation method thereof

An organic framework, tryptophan technology, applied in analytical materials, luminescent materials, material excitation analysis and other directions, can solve the problem of less tryptophan detection, and achieve the effect of good water stability and good water stability

Active Publication Date: 2017-12-05
浙江富昇科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are few studies on the use of luminescent metal-organic framework materials for the detection of amino acids, and even fewer studies and reports for the detection of tryptophan

Method used

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  • Metal-organic framework material for detecting tryptophan, and preparation method thereof
  • Metal-organic framework material for detecting tryptophan, and preparation method thereof
  • Metal-organic framework material for detecting tryptophan, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Using zinc chloride and 2-(4-pyridine) terephthalic acid, the metal-organic framework material synthesized by hydrothermal method, its specific synthesis route is as follows:

[0026] Dissolve 0.1 mmol of zinc chloride in 1 mL of deionized water to obtain a manganese salt solution with a molar concentration of 0.1 mol / L.

[0027] 0.2 mmol of 2-(4-pyridine) terephthalic acid and 10 mg of NaOH were mixed and dissolved in 5 mL of deionized water to obtain a mixed solution.

[0028] The zinc salt solution and the mixed solution were placed in a 25mL reaction kettle, sealed and kept at 160°C for 2 days, cooled to room temperature naturally, filtered, washed, and dried for 1.5 days to obtain the metal-organic framework [Zn(L) 0.5 (H 2 O) 1.2 ].

[0029] It can be obtained by single crystal X-ray diffraction analysis, [Zn(L) 0.5 (H 2 O) 1.2 ] has a long-range ordered crystal structure. Under the excitation of ultraviolet light with a wavelength of 310nm, a wide-range fl...

Embodiment 2

[0035] Using zinc nitrate and 2-(2-pyridine) terephthalic acid, the metal-organic framework material synthesized by hydrothermal method, its specific synthesis route is as follows:

[0036] Dissolve 0.2 mmol of zinc nitrate in 1 mL of deionized water to obtain a manganese salt solution with a molar concentration of 0.2 mol / L.

[0037] 0.2 mmol of 2-(2-pyridine) terephthalic acid and 15 mg of NaOH were mixed and dissolved in 5 mL of deionized water to obtain a mixed solution.

[0038] The zinc salt solution and the mixed solution were placed in a 25mL reaction kettle, sealed and kept at 160°C for 2 days, naturally cooled to room temperature, filtered, washed, and dried for 1 day to obtain the metal-organic framework [ZnL(H2 O) 1.5 ].

[0039] It can be obtained by single crystal X-ray diffraction analysis, [ZnL(H 2 O) 1.5 ] has a long-range ordered crystal structure. Under the excitation of ultraviolet light with a wavelength of 310nm, a wide-range fluorescence emission spe...

Embodiment 3

[0043] Using zinc sulfate and 2-(3-pyridine) terephthalic acid, the metal-organic framework material synthesized by hydrothermal method, its specific synthesis route is as follows:

[0044] Dissolve 0.05 mmol of zinc sulfate in 1 mL of deionized water to obtain a manganese salt solution with a molar concentration of 0.05 mol / L.

[0045] 0.1 mmol of 2-(3-pyridine) terephthalic acid and 12 mg of NaOH were mixed and dissolved in 5 mL of deionized water to obtain a mixed solution.

[0046] The zinc salt solution and the mixed solution were placed in a 25mL reaction kettle, sealed and kept at 150°C for 3 days, cooled to room temperature naturally, filtered, washed, and dried for 2 days to obtain the metal-organic framework [Zn(L) 0.8 h 2 O].

[0047] It can be obtained by single crystal X-ray diffraction analysis, [Zn(L) 0.8 h 2 O] has a long-range ordered crystal structure. Under the excitation of ultraviolet light with a wavelength of 310nm, a wide-range fluorescence emissio...

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Abstract

The invention discloses a metal-organic framework material for detecting tryptophan. The material has a long-range ordered crystal structure and regular porous channels, and the chemical formula of the material is [ZnLx (H2O)m], wherein L is an organic ligand containing a benzenecarboxylic acid group and a pyridyl group, x is 0.5 to 1, and m is 1 to 1.5. The material is prepared by a solvothermal technology, and the synthesis method has the advantages of simplicity, easiness in obtaining of raw materials, and high yield. The prepared material has a good water stability and has a good tryptophan detection performance. The luminescence intensity of the prepared material gradually increases with the increase of the tryptophan concentration, and is not interfered by other amino acids. The material enables highly-efficiently and specifically identify the tryptophan, is expected to be applied to the field of biomedicines and the like.

Description

technical field [0001] The invention relates to a metal-organic framework material and a preparation method thereof, in particular to a metal-organic framework material for tryptophan detection and a preparation method thereof. Background technique [0002] Tryptophan (Trp for short), as one of the essential amino acids for human body, plays an important role in human health. It is not only one of the components of DNA building blocks, it can affect the production of an essential neuromotor substance serotonin, but also helps the synthesis of niacin and heme, promotes riboflavin to play a role, and can effectively prevent Niacin deficiency and increased serotonin levels. At present, the methods for detecting tryptophan include potentiometric titration, fluorescence spectrophotometry, high performance liquid chromatography, electroanalysis, fluorescence spectroscopy, etc. Among them, fluorescence spectroscopy has good selectivity, high sensitivity, less sample consumption, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00C09K11/06G01N21/64
CPCC08G83/008C09K11/06C09K2211/188G01N21/6428
Inventor 钱国栋黄弋珂崔元靖杨雨
Owner 浙江富昇科技有限公司
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