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DNA functional gold nano-clusters (AuNCs) and preparation method thereof

A gold nanocluster, functionalized technology, applied in the direction of nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc.

Active Publication Date: 2017-12-15
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In summary, the ligands currently used to prepare AuNCs are small organic molecules or protein macromolecules, while AuNCs with nucleic acid macromolecules (such as DNA) as ligands have not been reported yet.

Method used

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  • DNA functional gold nano-clusters (AuNCs) and preparation method thereof
  • DNA functional gold nano-clusters (AuNCs) and preparation method thereof
  • DNA functional gold nano-clusters (AuNCs) and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0031] The main operating steps and conditions of this embodiment are the same as those of the preferred embodiment, but the amount of 6-mercaptocaproic acid added is changed from 2 milliliters to 1 milliliter. Example 1 The ultraviolet spectrum of the product DNA-AuNCs is as follows image 3 shown.

Embodiment 2

[0033]The main operation steps and conditions of this embodiment are the same as those in Example 1, but the amount of DNA aqueous solution added is changed from 350 microliters to 140 microliters. Example 2 The UV spectrum of the product DNA-AuNCs is as follows Figure 4 shown.

Embodiment 3

[0035] The main operating steps and conditions of the present embodiment are the same as those of the preferred embodiment, but the reaction time is changed from 12 hours to 8 hours. Example 3 The UV spectrum of the product DNA-AuNCs is as follows Figure 5 shown.

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Abstract

The invention discloses DNA functional gold nano-clusters (AuNCs) and a preparation method thereof. According to the technical scheme of the AuNCs, chloroauric acid serves as a gold source, single-stranded DNA, with the base number being smaller than 60, of 5' end modified sulfydryl serves as a nucleic acid type macromolecule ligand, sulfhydryl water-soluble small organic molecules serve as a small organic molecule ligand, under the alkaline solution condition, sodium borohydride serves as a reducing agent to conduct a reduction reaction, and thus the AuNCs are prepared. The technical scheme of the AuNCs has the advantages that the blanks of products related to existing AuNCs and the preparation technology of the AuNCs are filled.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and specifically refers to a DNA functionalized gold nanocluster and a preparation method thereof. Background technique [0002] Gold nanoclusters (AuNCs) are molecular-level aggregates composed of several to dozens of gold atoms at the core and organic molecules as protective groups. AuNCs not only have the advantages of metal core-organic shell structure, large specific surface area, and easy surface modification, but also exhibit good photostability and high fluorescence brightness. AuNCs have broad application prospects in the fields of biosensing and imaging, intracellular drug delivery, live cell imaging and cell tracking, cancer therapy, ultrasensitive molecular diagnosis, and image-guided therapy. [0003] Currently, the mainstream preparation method of AuNCs usually uses chloroauric acid as gold source and organic molecules with sulfhydryl groups as ligands. This method can...

Claims

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Application Information

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IPC IPC(8): B22F9/24B82Y40/00B82Y30/00
CPCB22F9/24B82Y30/00B82Y40/00
Inventor 林振坤齐金霞李磊苏宇钱紫君陈永辉金嘉乐徐艺包佳丽刘畅
Owner THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE