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Water-soluble polygoni cuspidate rhizoma et radix polysaccharide extract, as well as preparation method and use thereof

A technology of water-soluble polysaccharides and extracts, which is applied in the fields of anti-inflammatory, analgesic, and immune-regulating drugs. It can solve the problems of poor product quality, high production cost, and unsuitable for large-scale production, and achieve high yield and low production process cost. low effect

Inactive Publication Date: 2017-12-22
李仲昆
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a water-soluble polysaccharide extract of Polygonum cuspidatum and a preparation method thereof, which can effectively solve the problems of high production cost and low product quality when extracting water-soluble polysaccharides from Polygonum cuspidatum by acid extraction, alkali extraction, enzymatic hydrolysis and ultrasonic extraction. Problems of poor quality and unsuitability for mass production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1, the Polygonum cuspidatum water-soluble polysaccharide extract is obtained according to the following preparation method: first step, extract 95% ethanol of Polygonum cuspidatum medicinal material one or more times, collect the extract and recover ethanol, and evaporate residual ethanol in Polygonum cuspidatum; In the second step, after mixing Polygonum cuspidatum and distilled water at a mass ratio of 1:30 to 1:50, water extraction is carried out at a temperature of 85°C to 100°C for 4 hours to 6 hours, and the mixed solution after water extraction is filtered and collected Filtrate, the filtrate is concentrated to a quality that is 25 to 35 times the quality of Polygonum cuspidatum to obtain a concentrated solution; the third step, after the concentrated solution and sevage reagent is mixed together in a volume ratio of 1:1 to 1:2, the rotating speed is 120r / Shake for 30 to 50 minutes under the condition of min to 150r / min to carry out deproteinization treat...

Embodiment 2

[0019] The difference with the above-described embodiment is that the Polygonum cuspidatum is pulverized to the powder that can cross 60 mesh sieves to 80 mesh sieves.

Embodiment 3

[0020] Embodiment 3, as a preference of the above embodiment, in the third step, the sevage reagent is a mixed solution of chloroform and n-butanol mixed together in a volume ratio of 3:1 to 5:1.

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Abstract

The invention relates to the technical field of plant polysaccharides, and discloses a water-soluble polygoni cuspidate rhizoma et radix polysaccharide extract and a preparation method thereof. A water-soluble polygoni cuspidate rhizoma et radix polysaccharide has good anti-inflammation, analgesic and immunity regulation effects. The water-soluble polygoni cuspidate rhizoma et radix polysaccharide extract is obtained by the preparation method comprising the following steps: 1, degreasing; 2, water extraction; 3, deproteinization; 4, ethanol precipitation; 5, drying. A method for extracting the water-soluble polygoni cuspidate rhizoma et radix polysaccharide is provided, the shortcoming of gaps about the water-soluble polygoni cuspidate rhizoma et radix polysaccharide and the preparation method for the same in the field of plant polysaccharides is overcome, and a basis is provided for post development and utilization of the water-soluble polygoni cuspidate rhizoma et radix polysaccharide.

Description

technical field [0001] The invention relates to a water-soluble polysaccharide extract extracted from Polygonum cuspidatum, its extraction method, a pharmaceutical composition containing the polysaccharide extract, and the polysaccharide extract or its pharmaceutical composition as drugs for anti-inflammation, analgesia, and immune regulation the use of. Background technique [0002] The traditional Chinese medicine Polygonum cuspidatum is the rhizome of Polygonum cuspidatum. Mostly born in valleys, streams or banks, it is a perennial shrub-like herb. Polygonum cuspidatum is a commonly used traditional Chinese medicine. Traditional Chinese medicine believes that it is bitter in nature and taste, flat, and has the effects of dispelling wind, dampness, breaking silt, and dredging the menstrual flow. Polygonum cuspidatum is distributed in central and southern regions such as Jiangsu, Zhejiang, Jiangxi, Fujian, Shandong, and Henan, and can be excavated in spring and autumn. ...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P37/02A61P29/00
CPCC08B37/0003A61K31/715A61K36/704
Inventor 李仲昆
Owner 李仲昆
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