Medicine for preventing and treating brain stroke

Abstract

The invention discloses a medicine for preventing and treating brain stroke, especially ischemic stroke and application of the medicine, and the medicine for preventing and treating the brain stroke is ginsenoside Rb1. The invention relates to the medicine for preventing and treating the brain stroke, especially ischemic stroke, belonging to the field of pharmacy. The invention provides the application of the medicine for preventing and treating brain stroke in brain stroke, especially ischemic stroke; ginsenoside Rb1 has a good therapeutic activity in a rat model of brain injury induced by cerebral ischemia-reperfusion, and the experiment proves that ginsenoside Rb1 can obviously relieve the nerve function loss induced by cerebral ischemia-reperfusion in rats, significantly reduce the area of cerebral infarction caused by cerebral ischemia-reperfusion. Inflammatory reaction in the rat brain caused by cerebral ischemia-reperfusion increases the expression of TNF-alpha, IL-1belta and IL-6 proinflammatory cytokines on the focus cerebral side. Ginsenoside Rb1 can reverse the increasing phenomenon of the inflammatory cytokines in the focus cerebral side of the rat and can be used in the prevention and treatment of brain stroke, especially ischemic stroke.

Description

technical field [0001] The invention relates to a medicine for preventing and treating cerebral apoplexy, especially ischemic cerebral apoplexy, and belongs to the field of medicine. Background technique [0002] "Stroke" (cerebral stroke) is also known as "stroke" and "cerebrovascular accident" (cerebralvascularaccident, CVA). It is an acute cerebrovascular disease, which is a group of diseases that cause brain tissue damage due to the sudden rupture of blood vessels in the brain or the inability of blood to flow into the brain due to vascular obstruction, including ischemic and hemorrhagic stroke. The incidence of ischemic stroke is higher than that of hemorrhagic stroke, accounting for 60% to 70% of the total stroke. Occlusion and stenosis of the internal carotid artery and vertebral artery can cause ischemic stroke, most of which are over 40 years old, more men than women, and severe cases can cause death. Mortality from hemorrhagic stroke is high. According to the su...

AI Technical Summary

Problems solved by technology

[0003] At present, the methods for clinical treatment of stroke are mainly taking aspirin, clopidogrel, cerebrolysin tablets, Mecobalt, etc., all of which are relatively reliable in curative effect and targeted for treatment. Among them, aspirin is the basic drug for the prevention and treatment of stroke. Preventing the recurrence of stroke has a certain effect. Although the above treatment methods are effective, they can produce a variety of side effects and cause damage to the human body.

However, clinical application of aspirin shows that 47% of patients have drug resistance. Even aspirin enteric-coated tablets will cause a burden and impact on the gastrointestinal tract

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