Probiotic drops and a preparing method thereof

A technology of probiotics and drops, used in antifungal agents, topical antibacterial agents, pharmaceutical formulations, etc., to achieve the effects of inhibiting adhesion and reproduction, preventing common stubborn diseases, and improving unit sedimentation rate

Inactive Publication Date: 2018-01-16
JIANGSU WECARE BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, probiotics have strict requirements on the external environment. For example, bifidobacteria have a significant impact on oxygen stress, and it is difficult to maintain high activity for a long time in a normal or high temperature environment. Therefore, how to maintain the activity of probiotics for a long time can be better used to improve smoking population. The balance of the micro-ecological system in the mouth and nose, improving the resistance of smokers, has become a difficult problem

Method used

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  • Probiotic drops and a preparing method thereof
  • Probiotic drops and a preparing method thereof
  • Probiotic drops and a preparing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] The present embodiment provides a probiotic drop that prevents oral and nasal cavity diseases of smokers. In every 1000g of the probiotic drop, the amount of each component that needs to be added is: Lactobacillus salivarius bacterial suspension: 20-80g (comprising Glycerin 7.5-30g, Tween-80 0.075-0.3g, the rest is bacteria), palm oil 300g, sunflower oil 550-600g, non-transgenic soybean lecithin 10-70g, linoleic acid 10-25g.

[0040] Among them, the addition amount of the cell composition emulsion mainly affects the effect on the effect of inhibiting the adhesion and colonization of pathogenic bacteria in terms of the use effect. The addition amount of sunflower oil and linoleic acid mainly affects the sedimentation rate, dispersion uniformity and odor of the cell emulsion in the product. The amount of soybean lecithin added will change the fluidity and color of the product. Adding a high dose will make the product darker and increase the viscosity. On the contrary, the...

Embodiment 2

[0056] This example provides a probiotic drop that is free of potential allergens such as soybeans and can prevent oral and nasal cavity diseases in smokers. The specific formula can be seen in Table 2; the preparation method refers to the preparation method of Example 1, and will not be repeated.

[0057] Table 2 The second probiotic drop formula

[0058]

[0059]

[0060] For the probiotic drops of this embodiment, 25 degrees Celsius normal temperature and 37 degrees Celsius high temperature are used to track the stability at normal temperature, and the data collection results are as follows: figure 1 As shown, the number of viable bacteria can reach 10 within 18 months at room temperature 8 cfu / g, the number of viable bacteria can reach 10 within 8 months at high temperature 8 cfu / g.

[0061] The emulsion composed of cells in the probiotic drops of this embodiment is a compound probiotic formula, which can effectively reduce the adhesion of common pathogenic bacteri...

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Abstract

The invention relates to probiotic preparations, and particularly relates to probiotic drops and a preparing method thereof. The probiotic drops include, by mass, 1-2.5% of unsaturated fatty acid, 85-90% of vegetable oil, 1-7% of phospholipid oil and 2-8% of a probiotic suspension. The probiotic suspension includes glycerin, Tween-80 and probiotic cells. The method includes S1) mixing and equilibrizing the probiotic cells with the glycerin and the Tween-80 according to a certain ratio, and allowing the mixture to stand for 15-30 min to achieve a system equilibrium state to obtain the probioticsuspension; and S2) fully uniformly emulsifying the probiotic suspension with the unsaturated fatty acid, the vegetable oil and the phospholipid oil according to a certain ratio to obtain the probiotic drops. The probiotic drops can improve microecology in oral cavities and noses of smoking persons and improve resistance of the smoking persons.

Description

technical field [0001] The invention relates to a probiotic preparation, in particular to a probiotic drop and a preparation method thereof. Background technique [0002] Cigarette smoke has adverse effects on human health. Long-term smoking can increase the risk of lung cancer, chronic obstructive pulmonary disease, cardiovascular disease, periodontitis and other diseases. In addition, due to direct contact with cigarette smoke, the microbial communities in the mouth and nose are affected by toxic substances in the smoke, and their microecological ecology will also be greatly affected. [0003] Probiotics are mainly composed of most lactic acid bacteria, a small number of bacillus and yeast. Under the premise of a certain intake, they can produce many beneficial effects on the host such as improving immunity, regulating the intestinal tract, and balancing body fat. In the field of oral probiotics, probiotics can compete with oral pathogenic bacteria for oral mucosal bindin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/747A61K35/744A61K35/745A61K35/742A61K36/064A61K9/10A61K47/10A61K47/24A61K47/44A61P1/02A61P11/02A61P31/02A61P31/10
Inventor 方曙光陈珂可冯胜鹏姜甜陶纯长
Owner JIANGSU WECARE BIOTECHNOLOGY CO LTD
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