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Preparation method of nano-gold-silver-containing antibacterial material

A kind of antibacterial material, gold and silver technology, applied in the field of medicine and health, can solve the problem of not being available, and achieve the effect of improving antibacterial property, good bactericidal performance, and promoting release

Inactive Publication Date: 2018-01-19
重庆和其美科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, while nano-silver has strong antibacterial properties, it also has certain biological toxicity, which makes it unable to be well used in the field of biomaterials.

Method used

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  • Preparation method of nano-gold-silver-containing antibacterial material
  • Preparation method of nano-gold-silver-containing antibacterial material
  • Preparation method of nano-gold-silver-containing antibacterial material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A. Mix 0.36mL of egg white with 10.64mL of chloroauric acid with a concentration of 0.2μg / mL, adjust the pH value to 8, and react in a water bath at 90°C for 10 minutes to obtain a reaction mixture;

[0028] B. Add 1 mL of silver nitrate with a concentration of 1 μg / mL to the reaction mixture obtained in step A, and react in a water bath at 90° C. for 10 min to obtain an antibacterial material containing nanometer gold and silver.

Embodiment 2

[0030] A. Mix 0.36mL of duck egg white with 11mL of tetragold octachloride with a concentration of 0.5μg / mL, adjust the pH value to 10, and react in a water bath at 100°C for 20min to obtain a reaction mixture;

[0031] B. Add 1.1 mL of silver-ammonia solution with a concentration of 3.3 μg / mL to the reaction mixture obtained in step A, and react in a water bath at 100° C. for 20 minutes to obtain an antibacterial material containing nanometer gold and silver.

Embodiment 3

[0033] Mix 0.4mL of egg white with 11.3mL of gold chloride with a concentration of 1μg / mL, adjust the pH value to 11, and react in a water bath at 95°C for 30min to obtain a reaction mixture;

[0034] B. Add 1.3 mL of silver nitrate with a concentration of 5 μg / mL to the reaction mixture obtained in step A, and react in a water bath at 95° C. for 30 min to obtain an antibacterial material containing nanometer gold and silver.

[0035] 1. Minimum inhibitory concentration experiment

[0036] The minimum inhibitory concentration experiment tested the minimum concentration of the nano-gold and silver-containing antibacterial material prepared in Example 1 to inhibit the growth of Staphylococcus aureus and Escherichia coli. 2mL of nano-gold and silver solutions (concentrations of 3.13, 1.56, 0.78, 0.39, 0.2, 0.1, 0.05 μg / mL) and nano-silver solutions (concentrations of 40, 35, 30, 25, 12.5, 6.25, 3.13 μg / mL) respectively with 2mL concentration of 10 7 CFU / mL Escherichia coli and ...

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Abstract

The invention belongs to the field of health care technology and especially relates to a preparation method of a nano-gold-silver-containing antibacterial material. the preparation method comprises the following steps: A, uniformly mixing egg white and a gold-containing solution, regulating pH value to 8-11, and reacting in water bath to obtain a reaction mixed liquor; and B, adding a silver-containing solution into the reaction mixed liquor obtained after the reaction in the Step A, and reacting in water bath to obtain the nano-gold-silver-containing antibacterial material. In comparison withthe prior art, the nano-gold-silver-containing antibacterial material has efficient antibacterial property, is safe and reliable, and is beneficial to wound healing; and the preparation method is simple.

Description

technical field [0001] The invention belongs to the technical field of medicine and hygiene, and in particular relates to a preparation method of an antibacterial material containing nanometer gold and silver. Background technique [0002] As we all know, after a wound occurs on the human skin, it is easy to be infected by bacteria, causing many diseases such as suppuration, which is difficult to treat, especially the infection of some drug-resistant bacteria, which can even lead to death. Therefore, it is of great significance to find antibacterial drugs with a wide range of antibacterial properties, which can kill drug-resistant bacteria and have no biological toxicity. Therefore, researching more advanced antibacterial materials to achieve safe and effective sterilization and prevent bacterial infection has always been one of the directions of people's efforts. [0003] At present, there are many drugs used to treat wound infections, among which nanomaterials have attract...

Claims

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Application Information

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IPC IPC(8): A61K33/38A61K33/24A61K47/46A61P31/04
Inventor 蓝广芊李庆陆飞余堃卢必涛
Owner 重庆和其美科技有限公司
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