Cefpodoxime proxetil taste-masking granule and preparation method thereof

Abstract

The invention specifically discloses a cefpodoxime proxetil taste-masking granule and a preparation method thereof, belonging to the field of medicinal preparations. The taste-masking granule is prepared through mixing of a coated cefpodoxime proxetil pellet and a taste-masking particle, wherein the coated cefpodoxime proxetil pellet is of a structure composed of three layers, i.e., a drug-loadedpellet, a separating layer and a smoothing layer from interior to exterior. The main objective of the invention is to overcome the problems that current commercially-available cefpodoxime proxetil products immediately produce unpleasant bitter taste when child patients take the products; the taste of the cefpodoxime proxetil products is bad, which leads to poor medication compliance of child patients; and the cefpodoxime proxetil products have to be dissolved in water before taking, which leads to inconvenience in administration. To improve the medication compliance of children, the inherent bitter taste of cefpodoxime proxetil is totally masked, and components like a sweetener applicable to children are increased, so the bitter taste of the chemical drug is eliminated and fragrant smell is increased; and thus, child patients easily accept the granule and are pleasant to the fragrant smell, so the medication compliance of children is improved. Besides improvement of the medication compliance of children, the granule provided by the invention also overcomes the problem of inconvenience in administration of children by adding special adjuvants which allow children to take the granulethrough direct swallowing without dissolving in water into a prescription.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a taste-masking granule of cefpodoxime axetil and a preparation method thereof. Background technique [0002] Cefpodoxime Proxetil (Cefpodoxime Proxetil) is a third-generation oral broad-spectrum cephalosporin, which belongs to the β-lactam antibiotics. It was developed by Sankyo Company of Japan and was first listed in Japan in 1990. The trade names are: Bona, Shibo , Jiabo, Liangbo, Bowoxin, banan, Cepodem, Vantin, the chemical name is (6R,7R)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(form Oxyimino)-acetamido]-3-methoxymethyl-8-oxo-5-thio-1-azabicyclo-[4,2,0]oct-2-ene-2-carboxylic acid isopropyl Oxycarbonyloxyethyl ester. [0003] Cefpodoxime axetil is the prodrug of cefpodoxime, which itself has no antibacterial activity. After oral administration, it is absorbed through the intestinal tract and is hydrolyzed into cefpodoxime by non-specific esterase in the intestinal wall...

AI Technical Summary

Problems solved by technology

[0007] The present invention mainly solves the problem that the existing cefpodoxime axetil product on the market produces unpleasant bitter taste immediately after being taken by children, the mouthfeel is extremely bad, the children's medication compliance is poor, and the medicine needs to be washed with water, which leads to the inconvenience of taking the medicine. The compliance of children's medication completely covers the bitterness of the medicine itself, and adds ingredients such as sweeteners suitable for children to remove the bitterness of chemical medicines and increase the aroma, which is easy for children to accept and feel happy about the aroma, thus improving the quality of life. Children's Medication Adherence

In addition to improving the compliance of children taking medicine, special excipients are also added in the prescription to enable children to swallow the medicine without water, which solves the problem of inconvenient medicine for children.

Images