A kind of 4h-1,3-benzothiazine derivative with antibacterial activity and its synthesis method and application

A 4H-1, benzothiazine technology, applied in the directions of botanical equipment and methods, applications, biocides, etc., can solve the problems of complex substrates, harsh reaction conditions, low yields, etc., and achieves high yields, Easy to operate, cheap and easy to obtain solvent
CN107698537BActive Publication Date: 2020-11-06ZHEJIANG NORMAL UNIVERSITY
2 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG NORMAL UNIVERSITY
Publication Date
2020-11-06

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a 4H-1,3-benzothiazine derivative with antibacterial activity and a synthesis method and applications thereof. The structure of the 4H-1,3-benzothiazine derivative is represented by the formula (I), wherein in the formula (I), R1 represents a hydrogen atom, a chlorine atom, a bromine atom, or a methoxyl group, and R2 represents a hydrogen atom, a chlorine atom, a bromine atom, a methyl group, a methoxyl group, or a trifluoromethyl group. The 4H-1,3-benzothiazine derivative has a good antibacterial effect and can be used as a potential antiseptic.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of synthesis of heterocyclic compounds, in particular to a 4H-1,3-benzothiazine derivative and its synthesis method and application. Background technique

[0002] Compounds with 4H-1,3-benzothiazine have good pharmacological and biological activities ((a) Schilling, S.; Cynis, H.; Hoffmann, T.; Demuth, H.-U.US Pat. Appl.US 068699,2009; Chem.Abstr.2009,150,322579.(b) Anzini, M.; Giordani, A.; Makovec, F.; Cappelli, A.; Vomero, S.; Caselli, G.; Rovati, G.; Lucio, C. PCT Int. Pat. Appl. 040331, 2009; Chem. Abstr. 2009, 150, 374522. (c) Reynisson, J.; Court, W.; O'Neill, C.; Day, J.; Patterson, L.; McDonald, E.; Workman, P.; Katan, M.; Eccles, S.A. Bioorg. Med. Chem. 2009, 17, 3169.). For example, these compounds possess diuretic, anticancer and antiallergic activities. There are also many reports on the synthesis of such compounds ((a) Beilenson, B.; Hamer, F.M.J.Chem.Soc.1942, 98. (b) Besson, T.; Guillaumet, G.; La...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More