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A kind of 3D polypyrrole chitosan gelatin composite conductive material and preparation method thereof

A technology of polypyrrole chitosan gelatin and chitosan polymer, which is applied in the field of materials, can solve the problems such as the feasibility of 3D composite conductive patch materials that are rarely studied, and achieve good biocompatibility, high conductivity, and faster The effect of signaling

Active Publication Date: 2020-11-10
FIRST HOSPITAL OF SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, few studies have investigated the feasibility of 3D composite conductive patch materials for cardiac tissue engineering to enhance cardiomyocyte conductivity and cardiac electrical impulse propagation through their electrochemical properties.

Method used

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  • A kind of 3D polypyrrole chitosan gelatin composite conductive material and preparation method thereof
  • A kind of 3D polypyrrole chitosan gelatin composite conductive material and preparation method thereof
  • A kind of 3D polypyrrole chitosan gelatin composite conductive material and preparation method thereof

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Embodiment 1

[0044] This embodiment provides a preparation method of a 3D polypyrrole chitosan gelatin composite conductive material, comprising the following steps:

[0045] (1) preparation concentration is the acetic acid solution of 0.172mol / L, adds chitosan in described acetic acid solution, and controls the ratio of the mass of acetic acid and chitosan in described acetic acid solution to be 0.525:1, under 400rpm stirring condition Stir for 4h to fully mix to obtain chitosan acidic solution;

[0046] (2) adding pyrrole in the chitosan acidic solution described in step (1), and controlling the mass ratio of chitosan and pyrrole in the chitosan acidic solution is 1:0.294, stirred for 12h under 400rpm stirring condition Fully mix evenly to obtain chitosan-pyrrole mixed solution;

[0047] (3) Prepare a ferric chloride solution with a concentration of 0.67mol / L, slowly add the ferric chloride solution dropwise to the In the chitosan-pyrrole mixed solution, control the mass ratio of ferri...

Embodiment 2

[0051] This embodiment provides a preparation method of a 3D polypyrrole chitosan gelatin composite conductive material, comprising the following steps:

[0052] (1) preparation concentration is the acetic acid solution of 0.17mol / L, adds chitosan in described acetic acid solution, and controls the ratio of the mass of acetic acid and chitosan in described acetic acid solution to be 0.4:1, under 300rpm stirring condition Stir for 4h to fully mix to obtain chitosan acidic solution;

[0053] (2) adding pyrrole in the chitosan acidic solution described in step (1), and controlling the mass ratio of chitosan and pyrrole in the chitosan acidic solution to be 1:0.03, stirring for 12h under 300rpm stirring conditions Fully mix evenly to obtain chitosan-pyrrole mixed solution;

[0054] (3) Prepare a ferric chloride solution with a concentration of 0.067mol / L, slowly add the ferric chloride solution dropwise at a rate of 0.3ml / h to the In the chitosan-pyrrole mixed solution, control ...

Embodiment 3

[0058] This embodiment provides a preparation method of a 3D polypyrrole chitosan gelatin composite conductive material, comprising the following steps:

[0059] (1) preparation concentration is the acetic acid solution of 0.18mol / L, adds chitosan in described acetic acid solution, and controls the ratio of the mass of acetic acid and chitosan in described acetic acid solution to be 0.6:1, under 500rpm stirring condition Stir for 2h to fully mix to obtain chitosan acidic solution;

[0060] (2) adding pyrrole in the chitosan acidic solution described in step (1), and controlling the mass ratio of chitosan and pyrrole in the chitosan acidic solution to be 1:0.04, stirring for 8h under 500rpm stirring conditions Fully mix evenly to obtain chitosan-pyrrole mixed solution;

[0061] (3) Prepare a ferric chloride solution with a concentration of 0.67mol / L, slowly add the ferric chloride solution dropwise to the In the chitosan-pyrrole mixed solution, control the mass ratio of ferri...

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Abstract

The invention relates to a preparation method of a 3D polypyrrole chitosan gelatin composite electric conduction material. According to the preparation method, chitosan and pyrrole are used as raw materials, under the existence of a single electron reducing agent, namely, ferric trichloride, a polypyrrole- chitosan polymer is generated through reaction; then under the existence of a cross-linkingagent, namely, glutaraldehyde, the polypyrrole-chitosan polymer is cross-linked in pores of a gelatin sponge sheet, and thus the 3D polypyrrole chitosan gelatin composite electric conduction materialwith the porous structure is formed. The 3D polypyrrole chitosan gelatin composite electric conduction material prepared by adopting the method disclosed by the invention has relatively good mechanical strength, good biocompatibility, relatively high electric conduction property, relatively low impedance, and small voltage loss, and can accelerate transmission of Ca<2+> among myocardial cells. Anin-vitro evaluation experiment proves that the 3D polypyrrole chitosan gelatin composite electric conduction material has feasibility and effectiveness when used as a repair material in the heart of the rat to replace a whole-layer right ventricle outflow channel defect.

Description

technical field [0001] The invention belongs to the technical field of materials, and in particular relates to a 3D polypyrrole chitosan gelatin composite conductive material and a preparation method thereof. Background technique [0002] With the development of economy and society, the birth rate of children with congenital heart disease (Congenital Heart Disease, CHD) has dropped significantly; however, studies have shown that in Asia, including China, the birth rate of CHD is as high as 0.9%, which is a serious threat It is one of the diseases of children's healthy growth, which brings a heavy burden to individuals, families and society. In recent years, myocardial infarction has caused a large number of myocardial cell fiber death to form scars and fibrosis, destroying the original point activity conduction pathway of the heart, not only causing the decline of cardiac systolic and diastolic function, but also causing abnormal cardiac electrical activity, such as conducti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20A61L27/22A61L27/50A61L27/56
CPCA61L27/20A61L27/222A61L27/50A61L27/56A61L2430/20C08L51/02
Inventor 何生阎长平李仁科姜增誉李健丁宋慧芳
Owner FIRST HOSPITAL OF SHANXI MEDICAL UNIV
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