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Compound orlistat nanoemulsion and preparation method thereof

A technology of orlistat and nanoemulsion, which can be used in pharmaceutical formulations, emulsion delivery, and medical preparations containing active ingredients, etc., can solve the problems of fat-soluble vitamins and the loss of essential fatty acids in the human body, and achieve good stability.

Inactive Publication Date: 2018-03-02
CHENGDU LINGXI SHANGPIN TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, taking orlistat will cause the loss of fat-soluble vitamins and essential fatty acids

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0024] The compound orlistat nanoemulsion of this example, in terms of mass fraction, w (Tween-80) = 40%, w (PEG-400) = 0.25%, w (orlistat) = 2.5%, w (hemp seed oil) = 1.75%, w (evening primrose oil) = 0.75%, w (β-carotene) = 0.318%, w (vitamin D) = 0.001%, w (vitamin E) = 0.26%, w (vitamin K) = 0.001%, the balance is distilled water, and the sum of the mass percentages of the above raw materials is 100%.

[0025] Its preparation method comprises the following steps:

[0026] (1) Add Tween-80, orlistat, and PEG-400 into a four-necked flask, and stir to make them evenly mixed;

[0027] (2) Fix the four-necked flask under the condition of water bath, keep the water temperature at 40~60℃, after the raw materials are fully melted, start the stirrer, and the stirring speed is 150~200rpm;

[0028] (3) After the temperature of the raw materials in the four-neck flask reaches 40-60°C, stop stirring, add hemp seed oil, evening primrose oil, β-carotene, vitamins, vitamin E, and vitami...

Embodiment 2

[0034] In order to better realize the preparation of nanoemulsions in this example, it is further limited that the stirrers used in the preparation process are all magnetic stirrers. Other parts of this embodiment are the same as those of the foregoing embodiment, and will not be repeated here.

Embodiment 3

[0036] In order to better realize the preparation of nanoemulsions in this embodiment, it is further limited that in the step (4), the distilled water is dripped with a glue-tipped dropper. Other parts of this embodiment are the same as those of the foregoing embodiment, and will not be repeated here.

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Abstract

The invention discloses a compound orlistat nanoemulsion and a preparation method thereof. The compound orlistat nanoemulsion includes orlistat, beta-carotene, vitamin D, vitamin E, vitamin K, hemp seed oil and evening primrose oil as raw materials. The preparation method is mainly based on low-energy emulsification with further adjustment on details. The compound orlistat nanoemulsion can effectively overcome the deficiency of lipid-soluble vitamins and essential amino-acids during orally taking orlistat, thus achieving safe weight losing. The nanoemulsion is an O / W nanoemulsion and can be infinitely diluted in water. Detection via a transmission electron microscope proves that drop diameter is distributed in the range of 10-100 nm and the nanoemulsion is a yellow or colorless transparentliquid and has good stability.

Description

technical field [0001] The invention relates to the field of nanoemulsion preparation, in particular to a compound orlistat nanoemulsion and a preparation method thereof. Background technique [0002] Nanoemulsion, also known as microemulsion, is a thermodynamically stable, isotropic, transparent or translucent emulsion with a particle size of 1-100 nm formed spontaneously by water, oil, surfactants and co-surfactants. Homogeneous dispersion system. Generally speaking, nanoemulsions are divided into three types, namely oil-in-water nanoemulsion (O / W), water-in-oil type nanoemulsion (W / O and bicontinuous nanoemulsion (B.C), This dispersion system was first discovered and reported by Hoar and Schulman in 1943. It was not until 1959 that Schulman proposed the concept of "microemulsion". Since then, the theoretical and applied research of nanoemulsions has developed rapidly. At present, nanoemulsion technology It has penetrated into the fields of daily chemical industry, fine c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61K9/107A61K47/26A61P3/04A61P3/02A61K31/05A61K31/365A61K31/015A61K31/59A61K31/355A61K36/185
CPCA61K31/05A61K9/1075A61K31/015A61K31/355A61K31/365A61K31/59A61K36/185A61K36/60A61K47/26A61K2300/00
Inventor 姜迪蛟
Owner CHENGDU LINGXI SHANGPIN TECH CO LTD