Novel valnemulin premix as well as preparation technology and application thereof

Abstract

The invention relates to the technical field of relevant antibiotic products, and particularly provides a novel valnemulin premix product as well as a preparation technology and application thereof. The novel valnemulin premix product comprises valnemulin hydrochloride and many other auxiliary materials such as an anti-caking agent, an adsorbent, an adhesive and a diluent according to a certain ratio. The preparation technology of the novel valnemulin premix product comprises the following steps: 1), preparing materials; 2), crushing and sieving; 3), uniformly mixing; 4), pulping; 5), drying and granulating. The novel valnemulin premix product and pig feed are mixed or feeding, the weight of the novel valnemulin premix product is 0.2% that of the pig feed, and a mixture is continuously fedfor 7 days. The novel valnemulin premix product provided by the invention not only has high drug availability, good animal compliance and a significant therapeutic effect on sick pigs, but also is prepared by the simple preparation technology, is convenient to produce and use and small in side effects, and especially has a relatively good therapeutic effect of preventing and treating cough asthma, swine dysentery and hyperpyrexia syndromes of the sick pigs.

Description

technical field

[0001] The invention belongs to the related technical field of antibiotic products, and in particular relates to a novel warnemulin premix of veterinary antibiotics, as well as the preparation process and application of the antibiotic. Background technique

[0002] Valnemulin is a pleuromutilin semi-synthetic animal-specific antibiotic. It has strong antibacterial activity and a wide antibacterial spectrum. Mycoplasma, Mycoplasma gallisepticum, Mycoplasma pneumoniae), Streptococcus, Staphylococcus aureus, Actinobacillus, Pasteurella, Brachyspira hyodysenteriae and spirochete colonic pili-like all have good antibacterial activity, especially against Mycoplasma and Spirochetes are highly susceptible. Its antibacterial mechanism is similar to that of tiamulin, which inhibits protein synthesis by binding to the 50S subunit on the ribosome of pathogenic microorganisms. That is, by interacting with the ribosomes of pathogenic microorganisms, the synthesis of path...

Examples

Embodiment 1

[0036] Effects of different excipients and their combination on the processing technology of micro-powder of vonemulin

[0037] Ingredients: Warnemulin Hydrochloride, Aluminum Stearate, Talc, Wheat Bran, Rice Husk

[0038]Experimental method: take wheat bran and rice husks, stir-fry them with a slow fire until they are browned according to the traditional Chinese medicine method, and pulverize them for later use; take the materials according to the weight of each anti-caking agent component in Table 1, mix them fully and add them to 90 parts of hydrochloric acid Pulverize in a sealed low temperature (≤50°C) in Wernimulin, prepare samples 1 to 13, and pass the obtained samples 1 to 13 through a 200 mesh sieve respectively, record the time for all the powders to pass through the 200 mesh sieve, according to the The time of the test is recorded as "+++++" to "+" in order from short to long, and it is recorded as "-" if it cannot pass all of them (see Table 1 for the results).

...

Embodiment 2

[0089] Investigation of the curative effect of new-type wonimulin premix on swine panting disease:

[0090] Product: with existing commercially available " warnemulin hydrochloride premix " as contrast; According to the product quality evaluation result of embodiment 1, choose the sample 59 prepared in embodiment 1 as the novel warnemulin premix for testing agent products.

[0091] Case: 90 panting pigs with natural onset in a pig farm in Leshan (short and continuous coughing of pigs, which are most likely to be heard when stimulated by cold air after leaving the pen in the morning, or before and after driving and feeding, and coughing at the same time A small amount of nasal clearing fluid, grayish white viscous or purulent nasal fluid when seriously ill).

[0092] Method: Under the same feeding conditions, the diseased pigs were randomly divided into positive control group, test group and negative control group; the positive control group was fed with 0.3% mixing material o...

Embodiment 3

[0099] Investigation on the prevention and control effect of new-type warnimulin premix against porcine Clostridioides welchii disease:

[0100] Product: with existing commercially available " warnemulin hydrochloride premix " as contrast, according to the product quality evaluation result of embodiment 1, choose the sample 59 prepared in embodiment 1 as test with warnemulin premix product.

[0101] Case: 66 pigs suffering from swine dysentery in a pig farm in Deyang (sick pigs pulled soft feces, yellow thin feces, mixed with mucus or blood; became thin, growth stagnated. Treponema hyodysenteriae was tested positive).

[0102] Method: Under the same feeding conditions, the pigs under test were randomly divided into a test group, a positive control group and a negative control group; the test group was fed with 0.3% mixing material with the new-type warnimulin premix prepared in Example 1; The positive control group was fed with commercially available 10% warnemulin hydrochlor...

technical field

[0001] The invention belongs to the related technical field of antibiotic products, and in particular relates to a novel warnemulin premix of veterinary antibiotics, as well as the preparation process and application of the antibiotic. Background technique

[0002] Valnemulin is a pleuromutilin semi-synthetic animal-specific antibiotic. It has strong antibacterial activity and a wide antibacterial spectrum. Mycoplasma, Mycoplasma gallisepticum, Mycoplasma pneumoniae), Streptococcus, Staphylococcus aureus, Actinobacillus, Pasteurella, Brachyspira hyodysenteriae and spirochete colonic pili-like all have good antibacterial activity, especially against Mycoplasma and Spirochetes are highly susceptible. Its antibacterial mechanism is similar to that of tiamulin, which inhibits protein synthesis by binding to the 50S subunit on the ribosome of pathogenic microorganisms. That is, by interacting with the ribosomes of pathogenic microorganisms, the synthesis of path...

Examples

Embodiment 1

[0036] Effects of different excipients and their combination on the processing technology of micro-powder of vonemulin

[0037] Ingredients: Warnemulin Hydrochloride, Aluminum Stearate, Talc, Wheat Bran, Rice Husk

[0038]Experimental method: take wheat bran and rice husks, stir-fry them with a slow fire until they are browned according to the traditional Chinese medicine method, and pulverize them for later use; take the materials according to the weight of each anti-caking agent component in Table 1, mix them fully and add them to 90 parts of hydrochloric acid Pulverize in a sealed low temperature (≤50°C) in Wernimulin, prepare samples 1 to 13, and pass the obtained samples 1 to 13 through a 200 mesh sieve respectively, record the time for all the powders to pass through the 200 mesh sieve, according to the The time of the test is recorded as "+++++" to "+" in order from short to long, and it is recorded as "-" if it cannot pass all of them (see Table 1 for the results).

...

Embodiment 2

[0089] Investigation of the curative effect of new-type wonimulin premix on swine panting disease:

[0090] Product: with existing commercially available " warnemulin hydrochloride premix " as contrast; According to the product quality evaluation result of embodiment 1, choose the sample 59 prepared in embodiment 1 as the novel warnemulin premix for testing agent products.

[0091] Case: 90 panting pigs with natural onset in a pig farm in Leshan (short and continuous coughing of pigs, which are most likely to be heard when stimulated by cold air after leaving the pen in the morning, or before and after driving and feeding, and coughing at the same time A small amount of nasal clearing fluid, grayish white viscous or purulent nasal fluid when seriously ill).

[0092] Method: Under the same feeding conditions, the diseased pigs were randomly divided into positive control group, test group and negative control group; the positive control group was fed with 0.3% mixing material o...

Embodiment 3

[0099] Investigation on the prevention and control effect of new-type warnimulin premix against porcine Clostridioides welchii disease:

[0100] Product: with existing commercially available " warnemulin hydrochloride premix " as contrast, according to the product quality evaluation result of embodiment 1, choose the sample 59 prepared in embodiment 1 as test with warnemulin premix product.

[0101] Case: 66 pigs suffering from swine dysentery in a pig farm in Deyang (sick pigs pulled soft feces, yellow thin feces, mixed with mucus or blood; became thin, growth stagnated. Treponema hyodysenteriae was tested positive).

[0102] Method: Under the same feeding conditions, the pigs under test were randomly divided into a test group, a positive control group and a negative control group; the test group was fed with 0.3% mixing material with the new-type warnimulin premix prepared in Example 1; The positive control group was fed with commercially available 10% warnemulin hydrochlor...

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