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Manufacturing method of 3D printed artificial bone

A 3D printing and 3D printer technology, applied in the medical field, can solve the problems such as the inability to achieve personalized combined medication for different patients, prolong the sustained release time, and the bone cement cannot effectively carry the sustained release drugs, so as to achieve the step-by-step medication sustained release time. , the effect of prolonging the sustained release time

Active Publication Date: 2018-04-06
PARTICLE CLOUD BIOTECHNOLOGY (HANGZHOU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The embodiment of the present application provides a manufacturing method of 3D printed artificial bone, which solves the technical problem that the bone cement in the prior art cannot effectively carry sustained-release drugs, and cannot achieve personalized drug combination for different patients. Orthopedic surgery needs to carry a variety of different drugs at the same time, achieving the technical effect of step-by-step medication and prolonging the sustained release time

Method used

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  • Manufacturing method of 3D printed artificial bone
  • Manufacturing method of 3D printed artificial bone
  • Manufacturing method of 3D printed artificial bone

Examples

Experimental program
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Effect test

Embodiment 1

[0030] figure 1 It is a schematic flowchart of a manufacturing method of 3D printing artificial bone provided in the embodiment of the present application. Such as figure 1 As shown, the method includes:

[0031] Step 110: Obtain the first sensitive drug;

[0032] Specifically, the sensitive drug refers to the drug required for long-term sustained-release treatment of the target object during the treatment of osteomyelitis. Among them, according to the level of drug sensitivity, it can be divided into the first sensitive drug, the second sensitive drug, the third sensitive drug, the fourth sensitive drug, etc., wherein, according to the degree of sensitivity to the target object, it can be defined as : the sensitivity of the first sensitive drug is lower than that of the second sensitive drug, the sensitivity of the second sensitive drug is lower than that of the third sensitive drug, and the sensitivity of the third sensitive drug is lower than that of the second sensitive...

Embodiment 2

[0048] In order to realize the use of more moderately sensitive drugs and further improve the sustained release effect, the embodiment of the present application also provides a manufacturing method of 3D printing artificial bone, such as figure 2 As shown, the method includes:

[0049] Step 210: Obtain the third sensitive drug;

[0050] Step 220: Obtain a fourth sensitive drug, wherein the sensitivity of the second sensitive drug is lower than that of the third sensitive drug, and the sensitivity of the third sensitive drug is lower than that of the fourth sensitive drug drug;

[0051] Specifically, step 210 and step 220 can refer to the explanation of step 110 and step 120, the sensitivity of the second sensitive drug is lower than that of the third sensitive drug, and the sensitivity of the third sensitive drug Lower than the fourth sensitive drug.

[0052] Step 230: Dissolving the third sensitive drug in the solvent to make a third suspension;

[0053] Step 240: configu...

Embodiment 3

[0061] In order to realize the use of more moderately sensitive drugs and further improve the sustained release effect, the embodiment of this application also provides a manufacturing method of 3D printed artificial bone, please refer to image 3 , the method includes:

[0062] Step 310: Obtain a fifth sensitive drug, wherein the sensitivity of the fifth sensitive drug is higher than that of the first sensitive drug;

[0063] Step 320: dissolving the fifth sensitive drug in the solvent, and making a fifth suspension;

[0064] Step 330: After adding the first solid substance into the fifth suspension, add the calcium-containing compound with a weight percentage of 5%-50% to form a third solid substance.

[0065] Step 340: Obtain a sixth sensitive drug, wherein the sensitivity of the sixth sensitive drug is higher than that of the fifth sensitive drug;

[0066] Step 350: Dissolving the sixth sensitive drug in the solvent to make a sixth suspension;

[0067] Step 360: After a...

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Abstract

The invention provides a manufacturing method of a 3D printed artificial bone, and relates to the technical field of medicine. The manufacturing method comprises the following steps: obtaining a firstsensitive drug; obtaining a second sensitive drug, wherein the sensitivity of the first sensitive drug is lower than that of the second sensitive drug; dissolving 0.1 to 20 wt% of copolymer containing ethyl acetate into 1,4-dioxane to form a solvent; dissolving the first sensitive drug in the solvent to form a first turbid liquid; adding 5 to 50 wt% of calcium containing compounds into the firstturbid liquid to prepare a first solid; dissolving the second sensitive drug in the solvent to form a second turbid liquid; adding the first solid into the second turbid liquid, then adding 0.5 to 30wt% of calcium containing compounds to prepare a first paste like material; adding the first paste like material into a biological 3D printing machine, and carrying out printing to form a first artificial bone. The technical effects of step-by-step drug administration and prolonged sustained release time are realized.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for manufacturing 3D printed artificial bones. Background technique [0002] Osteomyelitis is an infection and destruction of bone caused by aerobic or anaerobic bacteria, mycobacteria and fungi. In the treatment of osteomyelitis, it is often necessary to penetrate the bone injury site and fill it with bone cement and other substances. [0003] However, in the process of realizing the technical solution of the invention in the embodiment of the present application, the inventor of the present application found that the above-mentioned technology has at least the following technical problems: [0004] In the prior art, in the clinical treatment of osteomyelitis, bone cement is used as a carrier or support to use slow-release drugs. However, the above solution cannot be absorbed by the body because the bone cement does not have degradability and biocompatibility. Simult...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/54A61L27/02
CPCA61L27/025A61L27/18A61L27/54A61L2300/604A61L2430/02C08L67/04
Inventor 李征宇曾庆丰
Owner PARTICLE CLOUD BIOTECHNOLOGY (HANGZHOU) CO LTD
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