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Micro-extraction stirring bar device for solid adsorption material and use method thereof

A technology of 3D printing and manufacturing method, applied in the medical field, can solve the problems that different types of orthopedic surgery cannot be effectively carried, and bone cement cannot effectively carry sustained-release drugs, and achieve the effect of accurate sustained-release drug release.

Inactive Publication Date: 2018-04-06
西安点云生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The embodiment of the present application provides a manufacturing method of 3D printed artificial bone, which solves the technical problem that the bone cement in the prior art cannot effectively carry sustained-release drugs, and cannot be used for different types of orthopedic operations, and has the ability to meet the needs of various orthopedic operations and The technical effect of being able to better carry sustained-release drugs

Method used

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  • Micro-extraction stirring bar device for solid adsorption material and use method thereof
  • Micro-extraction stirring bar device for solid adsorption material and use method thereof
  • Micro-extraction stirring bar device for solid adsorption material and use method thereof

Examples

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Embodiment 1

[0038] figure 1 It is a schematic flowchart of a manufacturing method of 3D printing artificial bone provided in the embodiment of the present application. like figure 1 As shown, the method includes:

[0039] Step 110: Obtain a first sensitive drug, wherein the first sensitive drug is used to characterize the drug sensitivity of the target subject;

[0040] Specifically, the sensitive drug refers to the drug required for long-term sustained-release treatment of the target object during the treatment of osteomyelitis. Among them, according to the level of drug sensitivity, it can be divided into the first sensitive drug, the second sensitive drug, and the third sensitive drug, wherein, according to the degree of sensitivity to the target object, it can be defined as: the first sensitive drug The sensitivity is lower than the second sensitive drug, and the sensitivity of the second sensitive drug is lower than that of the third sensitive drug.

[0041] Further, the setting ...

Embodiment 2

[0059] In order to achieve the use of more sensitive drugs and further improve the sustained release effect, such as figure 2 As shown, the embodiment of the present application also provides a manufacturing method of 3D printing artificial bone, the method comprising:

[0060] Step 210: After adding the second paste material into the biological 3D printer and printing based on the inner layer, the method further includes:

[0061] Step 220: Obtain a third sensitive drug, wherein the third sensitive drug is used for drug sensitivity of the target object, and the sensitivity of the second sensitive drug is lower than that of the third sensitive drug ;

[0062] Step 230: Dissolving the third sensitive drug in the solvent to make a third suspension;

[0063] Step 240: adding a calcium-containing compound with a weight percentage of 0.5%-30% into the third suspension to form a third paste material;

[0064] Step 250: adding the third paste material into the biological 3D print...

Embodiment 3

[0067] In order to further improve the sustained-release effect, the embodiment of the present application also provides a manufacturing method of 3D printing artificial bone, such as image 3 As shown, the method includes:

[0068] Step 310: obtaining the required first action time of the first sensitive drug;

[0069] Step 320: Obtain the total dose of the first sensitive drug according to the first action time;

[0070] Step 330: Determine the weight of the first paste-like material added to the biological 3D printer according to the total drug amount.

[0071] For the embodiment of the present application, different target objects may require different sustained release time according to the disease condition, individual physical condition, etc., so it is necessary to first determine the release time required for the sensitive drug, and more specifically, for the second A sensitive drug requires a first time of action. Further, the release time corresponding to the seco...

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Abstract

The invention relates to a micro-extraction stirring bar device for a solid adsorption material and a use method thereof. The device comprises an extraction bottle, a magnetic stirrer, a micro-extraction stirring bar, and a base. A magnet stirrer is arranged in the base. The base is snapped on the micro-extraction stirring bar. The micro-extraction stirring bar is a hollow glass tube, two ends ofthe hollow glass tube are sealed by porous films, and a solid adsorption material is filled in the porous films and the hollow glass. When the device is used, the micro-extraction stirring bar is snapped on the base. A conventional solid phase micro-extraction stirring bar has the disadvantages that magnets are filled in the hollow glass, a solid adsorption material is wrapped on the glass, duringthe stirring process, the adsorption material is worn by the rotation of the solid phase micro-extraction stirring bar and the bottom of the container, and the provided device solves the problems mentioned above. The base is arranged in the extraction bottle, the extraction bottle is placed on a magnetic stirring device, the magnet stirrer rotates in the magnetic stirring device to drive the micro-extraction stirring bar so as to stir the solution, and the extraction is carried out by the solid adsorption material in the micro-extraction stirring bar.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for manufacturing 3D printed artificial bones. Background technique [0002] Osteomyelitis is an infection and destruction of bone caused by aerobic or anaerobic bacteria, mycobacteria and fungi. In the treatment of osteomyelitis, it is often necessary to penetrate the bone injury site and fill it with bone cement and other substances. [0003] However, in the process of realizing the technical solution of the invention in the embodiment of the present application, the inventor of the present application found that the above-mentioned technology has at least the following technical problems: [0004] In the prior art, in the clinical treatment of osteomyelitis, bone cement is used as a carrier or support to use slow-release drugs. However, the above solution cannot be absorbed by the body because the bone cement does not have degradability and biocompatibility. At the...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/44A61L27/40A61L27/54A61L27/58B33Y70/00
CPCA61L27/46A61L27/446A61L27/54A61L27/58A61L2300/604A61L2430/02B33Y70/00C08L67/04
Inventor 李征宇曾庆丰
Owner 西安点云生物科技有限公司
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