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Intravenous nutrition preparation for children

A nutritional preparation and intravenous technology, applied in the field of medicine, can solve the problems of inability to meet the nutritional supplement needs of children, low calorie, not completely suitable for children, etc., and achieve the effects of convenient clinical use, high calorie, and cost reduction.

Active Publication Date: 2018-04-13
HUAREN PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For a long time, children in my country have been using glucose and electrolyte solutions for adults in clinical practice. Grape-like and electrolyte solutions for adults have low calories, such as mixed sugar electrolyte injection, which has a calorie of 420kcal/L, which cannot meet the

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Intravenous nutrition preparations for children include 1.242g potassium glycerophosphate, 0.617g L-calcium lactate, 0.561g L-sodium lactate, 0.107g magnesium acetate, 1.37mg zinc chloride, 85g glucose, 0.21g citric acid, appropriate amount of L-lactic acid, About 500mL of water for injection.

[0020] The preparation method is as follows:

[0021] (1) Concentrated formulation: Add about 40% volume of fresh water for injection at about 50°C to 60°C into the preparation container, start stirring, and put in 100% of the prescribed amount of citric acid and 0.12% (v / v) to 0.14% of the whole batch % (v / v) of lactic acid, put in 100% of the prescription amount of glucose, stir until completely dissolved, add 100% of the prescription amount of sodium lactate, magnesium acetate, zinc chloride, potassium glycerophosphate, and stir until completely dissolved; % (w / v) low-zinc needle charcoal, stir and keep warm for 15-20min;

[0022] (2) Dilute formulation: turn on the concent...

Embodiment 2

[0024] Intravenous nutrition preparations for children include 1.862g potassium glycerophosphate, 0.526g calcium glycerophosphate, 0.386g L-calcium lactate, 0.268g magnesium acetate, 1.37mg zinc chloride, 105g glucose, 0.21g citric acid, appropriate amount of L-lactic acid, About 500mL of water for injection.

[0025] The preparation method is as follows:

[0026] (1) Concentrated formulation: Add about 40% volume of fresh water for injection at about 50°C to 60°C into the preparation container, start stirring, and put in 100% of the prescribed amount of citric acid and 0.12% (v / v) to 0.14% of the whole batch % (v / v) of lactic acid, put in 100% of the prescription amount of glucose, stir until completely dissolved, add 100% of the prescription amount of sodium lactate, magnesium acetate, zinc chloride, potassium glycerophosphate, and stir until completely dissolved; % (w / v) low-zinc needle charcoal, stir and keep warm for 15-20min;

[0027] (2) Dilute formulation: turn on th...

Embodiment 3

[0029] Intravenous nutritional preparations for children include potassium glycerophosphate 1.552g, calcium glycerophosphate 0.263g, sodium L-lactate 0.281g, calcium L-lactate 0.502g, magnesium acetate 0.197g, zinc chloride 1.37mg, glucose 95g, citric acid 0.21g , appropriate amount of L-lactic acid, about 500mL of water for injection.

[0030] The preparation method is as follows:

[0031] (1) Concentrated formulation: Add about 40% volume of fresh water for injection at about 50°C to 60°C into the preparation container, start stirring, and put in 100% of the prescribed amount of citric acid and 0.12% (v / v) to 0.14% of the whole batch % (v / v) of lactic acid, put in 100% of the prescription amount of glucose, stir until completely dissolved, add 100% of the prescription amount of sodium lactate, magnesium acetate, zinc chloride, potassium glycerophosphate, and stir until completely dissolved; % (w / v) low-zinc needle charcoal, stir and keep warm for 15-20min;

[0032] (2) Dil...

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Abstract

The invention provides an intravenous nutrition preparation for children, and relates to the technical field of medicines. The intravenous nutrition preparation for children comprises potassium glycerophosphate, calcium glycerophosphate, calcium L-lactate, sodium L-lactate, magnesium acetate, zinc chloride, glucose and water for injection, the concentrations or the volumes of the above componentsare limited, the nutrition preparation further includes a pH adjuster, the pH adjuster is selected from citric acid and L- lactic acid, the pH value of the nutrition preparation is 4.8-5.8, and the osmotic pressure of the nutrition preparation is about 1232-1540 mOsm/L. The invention also provides a method for preparing the intravenous nutrition preparation for children. The preparation method includes concentrating and thinning. The intravenous nutrition preparation for children has high calorie, can timely provide nutrition for children, is simply proportioned, contains no amino acids, can be used together with other amino acid nutrition agents, and has low cost and other advantages.

Description

technical field [0001] The invention discloses a parenteral nutrition preparation for children and relates to the technical field of medicine. Background technique [0002] High-calorie glucose-electrolyte injection is suitable for patients who cannot receive nutritional supplements orally or enterally or are insufficiently supplemented, and are an important part of parenteral nutrition. Common indications include preoperative preparation for patients with external gastrointestinal fistula, external pancreatic fistula or major pancreatectomy, nutritional disorders and malnutrition after total bowel or small bowel resection; patients with severe burns, trauma and severe infection, Infants with congenital intestinal atresia and gastrointestinal obstruction; intractable infantile diarrhea, inflammatory bowel disease, renal failure, and liver failure; patients with poor general condition who receive chemotherapy for malignant tumors; those who cannot eat for a long time after ma...

Claims

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Application Information

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IPC IPC(8): A61K33/30A61K9/00A61P3/02A61P3/12A61K31/661A61K31/19A61K31/7004
CPCA61K9/0019A61K31/19A61K31/661A61K31/7004A61K33/30A61K2300/00
Inventor 谢苗苗冯新光宋群
Owner HUAREN PHARMACEUTICAL CO LTD
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