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Application of andrographolide in preparing medicines for treating depression

A technology for andrographolide, depression, applied in the field of medicine, can solve the problems of no report on the application of andrographolide, less than 70% effective rate, few side effects, etc., and achieves the effect of relieving and treating depression

Inactive Publication Date: 2018-04-20
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current clinical antidepressants are mostly chemical synthetic drugs, mainly including tricyclic antidepressants, tetracyclic antidepressants, selective serotonin reuptake blockers and monoamine oxidase inhibitors; although there are many types, there are The efficiency is often less than 70%, and there are many side effects and the possibility of recurrence[4,5]
[0005] But there is no report about the application of andrographolide in the preparation of drugs for the treatment of depression

Method used

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  • Application of andrographolide in preparing medicines for treating depression
  • Application of andrographolide in preparing medicines for treating depression
  • Application of andrographolide in preparing medicines for treating depression

Examples

Experimental program
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Embodiment 1

[0024] 1. Experimental method:

[0025] 1. Chronic Unpredictable Stress Model (CUMS)

[0026] Male C57BL6 mice (8 weeks old) were used as experimental subjects, randomly divided into groups, 10 mice in each group, except for the normal group with 5 mice in each cage, the other groups were reared in single cages. The model process lasted for 8 weeks, and the mice were given a stimulus every day, including fasting for 24 hours, water deprivation for 24 hours, tail pinching for 1 minute, humid environment, day and night reversal, tail hanging for 5 minutes, and swimming in ice water (4°C, 4 minutes). On average, each stimulus was presented once a week, and the sequence of stimuli was different from week to week, making it impossible for mice to predict which stimulus to expect. In the last two weeks, at the same time as the stimulation, the administration was started every day according to the group and the body weight, in the form of intraperitoneal injection, at a dose of 10ml...

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Abstract

The invention relates to the technical field of medicines, and in particular to an application of andrographolide in preparing medicines for treating depression. Based upon researches with the assistance of various depression animal models and test methods, the andrographolide, through intraperitoneal injection, can obviously reverse various depression-like behaviors caused by the depression models, with efficacy intensity not weaker than that of a classical clinical anti-depression medicine, namely fluoxetine; therefore, as a completely new pharmacological effect, the andrographolide can be used for effectively relieving and treating the depression.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of andrographolide in the preparation of medicines for treating depression. Background technique [0002] Depression is a common affective disorder-type mental disease, and its incidence rate has been high; this mental disease not only affects the individual's work, study and quality of life, but also seriously affects the stability of the family and society due to its high suicidal tendency; the main It is manifested as depressed mood, decreased interest, pessimism, memory loss, lack of initiative, etc. (references: [1]. ]. Krishnan, V., Nestler, E.J., 2008. The molecular neurobiology of depression. Nature 455, 894-902. [3]. Shelton, R.C., 2007. The molecular neurobiology of depression. Psychiatr. Clin. North Am. .). The current clinical antidepressants are mostly chemical synthetic drugs, mainly including tricyclic antidepressants, tetracyclic antidepressants...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P25/24
CPCA61K31/365
Inventor 江波王金亮王英杰王浩王园
Owner NANTONG UNIVERSITY
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